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Chemical composition and hypoglycemic activity of Edgeworthia gardneri
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Jie-xue WANG1, Guo TAO1, Fan YANG1, Min YANG1, Qing-qin FENG1, Ming-fang MA3, Jing CHEN2, *
Acta Pharmaceutica Sinica | 2021, 56(5) : 1434 - 1438
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Acta Pharmaceutica Sinica | 2021, 56(5): 1434-1438
• Original Articles •
Chemical composition and hypoglycemic activity of Edgeworthia gardneri
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Jie-xue WANG1, Guo TAO1, Fan YANG1, Min YANG1, Qing-qin FENG1, Ming-fang MA3, Jing CHEN2, *
Affiliations
  • 1. College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China
  • 2. Tibet University of Tibetan Medicine, Lhasa 850000, China
  • 3. Qinghai Province Institute for Food Control, Xining 810008, China
Published: 2021-05-12 doi: 10.16438/j.0513-4870.2020-1970
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Seven compounds were isolated from the alcohol extract of Edgeworthia gardneri by various technologies, including silica gel, Sephadex LH-20 and high performance liquid chromatography, and were identified as edgeworthiaside A (1), 2, 4, 6-trichlorol-3-methyl-5-methoxy-phenol 1-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranoside (2), 2, 6-dimethoxy-4-(2-propen-1-yl)phenyl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside (3), eugenol rutinoside (4), tiliroside (5), edgeworoside C (6), and salicylic acid (7). Compound 1 is a new chlorophenyl glycoside and 2-4 were isolated for the first time from Edgeworthia gardneri. The in vitro inhibition of α-glucosidase showed that the inhibition rate of compounds 1 and 2 were similar to acarbose.

Tibetan material herb  /  Edgeworthia gardneri  /  edgeworthiaside A  /  α-glucosidase  /  chemical constituent
Jie-xue WANG, Guo TAO, Fan YANG, Min YANG, Qing-qin FENG, Ming-fang MA, Jing CHEN. Chemical composition and hypoglycemic activity of Edgeworthia gardneri[J]. Acta Pharmaceutica Sinica, 2021 , 56 (5) : 1434 -1438 . DOI: 10.16438/j.0513-4870.2020-1970
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Article Info
doi: 10.16438/j.0513-4870.2020-1970
  • Receive Date：2020-12-28
  • Online Date：2025-12-18
  • Published：2021-05-12
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  • Received：2020-12-28
  • Revised：2021-01-12
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Affiliations
    1. College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China
    2. Tibet University of Tibetan Medicine, Lhasa 850000, China
    3. Qinghai Province Institute for Food Control, Xining 810008, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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