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Research progress of polymer mixed micelles based on improving the efficacy of antitumor drugs
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Zhong-cheng KE1, Yin-yu SUN1, Xiao-ling CHENG2, Zhen-hai ZHANG1, Huan WANG1, Chang-jiang Li1, *, Xiao-bin JIA3, *
Acta Pharmaceutica Sinica | 2021, 56(11) : 3047 - 3059
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Acta Pharmaceutica Sinica | 2021, 56(11): 3047-3059
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Research progress of polymer mixed micelles based on improving the efficacy of antitumor drugs
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Zhong-cheng KE1, Yin-yu SUN1, Xiao-ling CHENG2, Zhen-hai ZHANG1, Huan WANG1, Chang-jiang Li1, *, Xiao-bin JIA3, *
Affiliations
  • 1. Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan 245041, China
  • 2. Health Supervision Institute of Tunxi, Huangshan 245000, China
  • 3. College of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China
Published: 2021-11-12 doi: 10.16438/j.0513-4870.2021-0413
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Polymeric micelles have become a potential drug carrier. However, some single-copolymer micelles often have some performance defects, such as low drug loading, poor stability and weak response to microenvironment. Mixed micelles self-assembled from two or more dissimilar macromolecular polymers provides a direct and convenient approach to improve drug delivery. This paper attempts to review the internal force, preparation and characterization, performance advantages and biological activity of mixed polymer micelles, aims to show the advantages of polymer mixed micelles, analyzes the problems and shortcomings, and hopes to provide reference for the development of anti-tumor nano-micelles.

mixed micelle  /  single-copolymer micelle  /  anti-tumor  /  carrier material
Zhong-cheng KE, Yin-yu SUN, Xiao-ling CHENG, Zhen-hai ZHANG, Huan WANG, Chang-jiang Li, Xiao-bin JIA. Research progress of polymer mixed micelles based on improving the efficacy of antitumor drugs[J]. Acta Pharmaceutica Sinica, 2021 , 56 (11) : 3047 -3059 . DOI: 10.16438/j.0513-4870.2021-0413
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Article Info
doi: 10.16438/j.0513-4870.2021-0413
  • Receive Date：2021-03-22
  • Online Date：2025-12-18
  • Published：2021-11-12
Article Data
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History
  • Received：2021-03-22
  • Revised：2021-06-08
Funding
Affiliations
    1. Research Center of Chinese Medicine Efficacy and Health Technology, Huangshan University, Huangshan 245041, China
    2. Health Supervision Institute of Tunxi, Huangshan 245000, China
    3. College of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China
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https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-0413
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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