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Sialic acid binding receptors—impressive targets for tumor treatment
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Cong LI, Chui-zhong FAN, Xin-yang YAN, Xin GAO, Xiao-xue LAI, Yan-zhi SONG, Xin-rong LIU, Yi-hui DENG*
Acta Pharmaceutica Sinica | 2021, 56(11) : 3060 - 3073
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Acta Pharmaceutica Sinica | 2021, 56(11): 3060-3073
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Sialic acid binding receptors—impressive targets for tumor treatment
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Cong LI, Chui-zhong FAN, Xin-yang YAN, Xin GAO, Xiao-xue LAI, Yan-zhi SONG, Xin-rong LIU, Yi-hui DENG*
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  • School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
Published: 2021-11-12 doi: 10.16438/j.0513-4870.2021-0543
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Glycosylation abnormalities are common in all stages of tumor development, and sialic acid (SA) modified polysaccharides have been found highly expressed on many different types of tumor cells. These highly sialylated tumor cells promote the formation of tumor immunosuppressive environment and help tumor cells gain metastatic potential by interacting with SA binding receptors Siglecs/selectins expressed on peripheral immune cells or endothelial cells. Related theoretical studies have promoted the development of tumor therapeutic strategies by targeting SA-binding receptors, mainly including specific antibodies trastuzumab (Mylotarg) or polysaccharides that block the interaction between Siglecs/selectins and its ligands, as well as nano-based drug delivery systems modified with SA and its derivatives. This article reviews the specific mechanisms of how SA-binding receptor Siglecs/selectins-mediated interactions contribute to tumor development and metastasis, and tumor therapeutic strategies by targeting SA-binding receptors, as well as makes a rational evaluation and reflection on these therapeutic strategies.

sialic acid  /  immunologic receptor  /  neoplasm  /  anti-idiotypic antibody  /  glycosaminoglycan  /  drug delivery system
Cong LI, Chui-zhong FAN, Xin-yang YAN, Xin GAO, Xiao-xue LAI, Yan-zhi SONG, Xin-rong LIU, Yi-hui DENG. Sialic acid binding receptors—impressive targets for tumor treatment[J]. Acta Pharmaceutica Sinica, 2021 , 56 (11) : 3060 -3073 . DOI: 10.16438/j.0513-4870.2021-0543
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doi: 10.16438/j.0513-4870.2021-0543
  • Receive Date：2021-04-13
  • Online Date：2025-12-18
  • Published：2021-11-12
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  • Received：2021-04-13
  • Revised：2021-05-31
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    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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