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Research advances of EMT progression of pulmonary fibrosis mediated by non-coding RNAs and natural medicines interventions
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De-wei ZHU, Qun YU, Yun-hui SHEN*
Acta Pharmaceutica Sinica | 2021, 56(11) : 2934 - 2942
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Acta Pharmaceutica Sinica | 2021, 56(11): 2934-2942
• Special Reports: Recent Advances in Visceral Organ Fibrosis and Antifibrotic Drug Discovery •
Research advances of EMT progression of pulmonary fibrosis mediated by non-coding RNAs and natural medicines interventions
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De-wei ZHU, Qun YU, Yun-hui SHEN*
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  • School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2021-11-12 doi: 10.16438/j.0513-4870.2021-0971
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Epithelial mesenchymal transition (EMT) is a reprogramming process of epithelial to mesenchymal transition, in which epithelial cells lose polarity and intercellular adhesion and acquire stronger migration and invasion ability similar to mesenchymal cells. EMT is a critical step during the pathogenesis of pulmonary fibrosis. Lung epithelial cells can differentiate into myofibroblasts through EMT, which accelerates the fibrosis process. In recent years, a large number of studies have shown that non-coding RNAs (ncRNAs) are involved in the EMT process of lung epithelial cells, at the same time, some natural medicines were found to prevent and treat pulmonary fibrosis by intervening in ncRNAs related to pulmonary fibrosis. In this review, we summarize the expression change and biological function of vital ncRNAs in EMT progression during pulmonary fibrosis, as well as the research progress of EMT related ncRNA mediated by natural medicines on pulmonary fibrosis, aiming to provide new insights into the research of ncRNAs and the exploration of new pharmacological targets of natural medicine.

pulmonary fibrosis  /  epithelial mesenchymal transition  /  non-coding RNA  /  natural medicine  /  mechanism
De-wei ZHU, Qun YU, Yun-hui SHEN. Research advances of EMT progression of pulmonary fibrosis mediated by non-coding RNAs and natural medicines interventions[J]. Acta Pharmaceutica Sinica, 2021 , 56 (11) : 2934 -2942 . DOI: 10.16438/j.0513-4870.2021-0971
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Year 2021 volume 56 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2021-0971
  • Receive Date：2021-06-30
  • Online Date：2025-12-18
  • Published：2021-11-12
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  • Received：2021-06-30
  • Revised：2021-08-01
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    School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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