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Tumour cytotoxic activities of a new eudesmane-type sesquiterpenoid from Artemisia deversa Diels
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Bin ZHANG1, 2, *, Guo-ping ZENG1, 2, Xiao-qin XIONG1, 2, Qiao-qiao ZHOU1, 2
Acta Pharmaceutica Sinica | 2021, 56(10) : 2830 - 2834
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Acta Pharmaceutica Sinica | 2021, 56(10): 2830-2834
• Original Articles •
Tumour cytotoxic activities of a new eudesmane-type sesquiterpenoid from Artemisia deversa Diels
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Bin ZHANG1, 2, *, Guo-ping ZENG1, 2, Xiao-qin XIONG1, 2, Qiao-qiao ZHOU1, 2
Affiliations
  • 1. Department of Chemistry and Life Science, Hubei University of Education, Wuhan 430205, China
  • 2. Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients, Wuhan 430205, China
Published: 2021-10-12 doi: 10.16438/j.0513-4870.2021-0781
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Five compounds were isolated from an ethanol extract of Artemisia deversa Diels by solvent extraction, Diaion HP-20, CHP20/P120 MCI, Sephadex LH-20, silica gel and preparative high performance liquid chromatography. Their structures were elucidated by MS, NMR and X-ray as artemideversal (1), 7-hydroxy-6-methoxycoumarin (2), 6, 7-dimethoxycoumarin (3), caffeic acid (4) and 4', 5, 7-trihydroxy flavone (5). Compound 1 is a new eudesmane-type sesquiterpene. In vitro cytotoxic activities of the five compounds were explored by MTT testing with HepG2, A549, HeLa and MRC-5 cell lines. Results show that compounds 1 and 5 significantly inhibited cellular proliferation. The IC50 of compound 1 in A549 and HepG2 cells was 8.36 and 16.51 μmol·L-1; the IC50 of compound 5 in A549 and HepG2 cells was 17.06 and 7.95 μmol·L-1.

Artemisia deversa Diels  /  chemical composition  /  artemideversal  /  cytotoxic activity
Bin ZHANG, Guo-ping ZENG, Xiao-qin XIONG, Qiao-qiao ZHOU. Tumour cytotoxic activities of a new eudesmane-type sesquiterpenoid from Artemisia deversa Diels[J]. Acta Pharmaceutica Sinica, 2021 , 56 (10) : 2830 -2834 . DOI: 10.16438/j.0513-4870.2021-0781
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Article Info
doi: 10.16438/j.0513-4870.2021-0781
  • Receive Date：2021-05-24
  • Online Date：2025-12-18
  • Published：2021-10-12
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  • Received：2021-05-24
  • Revised：2021-06-24
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Affiliations
    1. Department of Chemistry and Life Science, Hubei University of Education, Wuhan 430205, China
    2. Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients, Wuhan 430205, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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