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The effect of high-altitude hypoxia on drug metabolism is mediated by gut microbiota
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Xue BAI1, Gui-qin LIU1, Jian-xin YANG1, Ya-bin DUAN1, Jun-bo ZHU1, Xiang-yang LI*, 1, 2
Acta Pharmaceutica Sinica | 2021, 56(10) : 2787 - 2796
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Acta Pharmaceutica Sinica | 2021, 56(10): 2787-2796
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The effect of high-altitude hypoxia on drug metabolism is mediated by gut microbiota
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Xue BAI1, Gui-qin LIU1, Jian-xin YANG1, Ya-bin DUAN1, Jun-bo ZHU1, Xiang-yang LI*, 1, 2
Affiliations
  • 1. Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
  • 2. State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China
Published: 2021-10-12 doi: 10.16438/j.0513-4870.2021-0805
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The activity and expression of drug metabolizing enzymes and transporters changes significantly under high altitude hypoxia. The gut microbiota is an important factor affecting the metabolism of drugs through direct and indirect actions, changing the bioavailability, biological activity or toxicity of drugs and affecting the efficacy and safety of drugs. High altitude hypoxia significantly changes the structure and diversity of the gut microbiota, which may play a role in drug metabolism. This article reviews the effects of high-altitude hypoxia on the gut microbiota and the effects these changes on drug metabolism.

high altitude hypoxia  /  drug metabolism  /  gut microbiota  /  CYP450
Xue BAI, Gui-qin LIU, Jian-xin YANG, Ya-bin DUAN, Jun-bo ZHU, Xiang-yang LI. The effect of high-altitude hypoxia on drug metabolism is mediated by gut microbiota[J]. Acta Pharmaceutica Sinica, 2021 , 56 (10) : 2787 -2796 . DOI: 10.16438/j.0513-4870.2021-0805
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Year 2021 volume 56 Issue 10
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Article Info
doi: 10.16438/j.0513-4870.2021-0805
  • Receive Date：2021-05-29
  • Online Date：2025-12-18
  • Published：2021-10-12
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History
  • Received：2021-05-29
  • Revised：2021-07-22
Funding
Affiliations
    1. Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
    2. State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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