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Research progress of pulmonary particle movement mechanical model
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Du-chang XU1, Kai-cheng LAI1, Yi-guang JIN2, Yuan-qing XU1, *
Acta Pharmaceutica Sinica | 2021, 56(10) : 2622 - 2629
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Acta Pharmaceutica Sinica | 2021, 56(10): 2622-2629
• Special Reports: Inhalation Drug Delivery System •
Research progress of pulmonary particle movement mechanical model
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Du-chang XU1, Kai-cheng LAI1, Yi-guang JIN2, Yuan-qing XU1, *
Affiliations
  • 1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China
  • 2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
Published: 2021-10-12 doi: 10.16438/j.0513-4870.2021-0651
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The movement and deposition of inhaled particles in the lung tissue have an important influence on the respiratory physiology of human body. The corresponding particle dynamics model plays a vital role in exploring the pathogenic factors and treatment methods of lung diseases. Such as evaluating the optimal design of pulmonary atomization drug delivery and the impact of particulate air pollutants on the lung. According to the different knowledge and modeling methods, this paper classifies, combs and analyzes several representative particle dynamics models in lung airways in recent years. We divided the mechanism models into the biological model, physical model and numerical simulation model. The biological models include in vivo imaging and pharmacokinetic methods; physical models include bionic and microfluidic chip models; the numerical models include respiratory tract model, airflow model and particle model. Moreover, the numerical solution and fluid-structure-interaction models were also reviewed, especially the application prospect of the lattice Boltzmann method.

lung  /  mechanical model  /  particle movement  /  numerical computer simulation  /  lattice Boltzmann method
Du-chang XU, Kai-cheng LAI, Yi-guang JIN, Yuan-qing XU. Research progress of pulmonary particle movement mechanical model[J]. Acta Pharmaceutica Sinica, 2021 , 56 (10) : 2622 -2629 . DOI: 10.16438/j.0513-4870.2021-0651
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Article Info
doi: 10.16438/j.0513-4870.2021-0651
  • Receive Date：2021-04-29
  • Online Date：2025-12-18
  • Published：2021-10-12
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History
  • Received：2021-04-29
  • Revised：2021-05-20
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    1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China
    2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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