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Chemical constituents of the fresh roots of Huaizhong NO.1 Rehmannia glutinosa
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Xi-ling FAN1, 2, Yan-ling LIU1, 2, Yan-gang CAO1, 2, Ying-jie REN1, 2, Meng-na WANG1, 2, Xu CHEN1, 2, Chen HE1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(11) : 3097 - 3103
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Acta Pharmaceutica Sinica | 2021, 56(11): 3097-3103
• Original Articles •
Chemical constituents of the fresh roots of Huaizhong NO.1 Rehmannia glutinosa
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Xi-ling FAN1, 2, Yan-ling LIU1, 2, Yan-gang CAO1, 2, Ying-jie REN1, 2, Meng-na WANG1, 2, Xu CHEN1, 2, Chen HE1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Affiliations
  • 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China
Published: 2021-11-12 doi: 10.16438/j.0513-4870.2021-0777
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Twenty compounds were isolated and purified from the fresh roots of Huaizhong NO.1 Rehmannia glutinosa by various chromatographic techniques such as Toyopreal HW-40C, Sephadex LH-20, silica gel and semi-preparative HPLC. Their structures were identified by analysis of physicochemical properties and spectral data, and determined as 3-methyl-2-(hydroxymethyl)-4H-pyrone-4-one (1), 3-amino-2-pyridine ethanol (2), (5'S)-2-oxo-N-phenylpyrrolidine-3-carboxamide (3), L-pyroglutamic acid methyl ester (4), indazole (5), uridine (6), adenosine (7), rehmanalkaloid C (8), 1-(3-ethylphenyl)-1, 2-ethanediol (9), (3-ethylphenyl)-1, 2-ethanediol (10), 2-hydroxymethylphenyl-1-O-β-D-glucopyranoside (11), mussaenoside (12), 11-methylforsythide (13), 7-deoxygardoside (14), 1-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (15), 6-deoxy-D-mannono-1, 4-lactone (16), monoethylfumarate (17), daphneresinol (18), dihydroquercetin (19), rhamnopyranosyl vaniloyl (20). Compound 1 is a new compound, named as 3-methyl-2-(hydroxymethyl)-4H-pyrone-4-one, compounds 2 and 3 are new natural products, and compounds 4, 5, 9-11, 13, 14 and 16-19 are isolated from Rehmannia for the first time.

Scrophulariaceae  /  fresh Rehmannia glutinosa  /  chemical component  /  3-methyl-2-(hydroxymethyl)-4H-pyrone-4-one  /  3-amino-2-pyridine ethanol  /  (5'S)-2-oxo-N-phenylpyrrolidine-3-carboxamide
Xi-ling FAN, Yan-ling LIU, Yan-gang CAO, Ying-jie REN, Meng-na WANG, Xu CHEN, Chen HE, Xiao-ke ZHENG, Wei-sheng FENG. Chemical constituents of the fresh roots of Huaizhong NO.1 Rehmannia glutinosa[J]. Acta Pharmaceutica Sinica, 2021 , 56 (11) : 3097 -3103 . DOI: 10.16438/j.0513-4870.2021-0777
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Article Info
doi: 10.16438/j.0513-4870.2021-0777
  • Receive Date：2021-05-24
  • Online Date：2025-12-18
  • Published：2021-11-12
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History
  • Received：2021-05-24
  • Revised：2021-06-29
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Affiliations
    1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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