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Research progress of natural polysaccharides and their nano-sized drug delivery systems in regulating tumor microenvironment
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Tao HAN1, Yan CHEN1, 2, *, Ding QU1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(12) : 3212 - 3223
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Acta Pharmaceutica Sinica | 2021, 56(12): 3212-3223
• Special Reports Ⅰ: Anti-tumor Preparations of Traditional Chinese Medicine •
Research progress of natural polysaccharides and their nano-sized drug delivery systems in regulating tumor microenvironment
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Tao HAN1, Yan CHEN1, 2, *, Ding QU1, 2, *
Affiliations
  • 1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
  • 2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
Published: 2021-12-12 doi: 10.16438/j.0513-4870.2021-0396
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Natural polysaccharides with good biocompatibility and unique tumor immunomodulatory activity are becoming an important adjuvant anticancer therapy in clinic. In the field of pharmaceutics, natural polysaccharides can be used as not only bioactive components but also drug delivery carriers, as well as tumor-targeted ligands. Besides, various novel drug delivery systems based on natural polysaccharides exhibit unique advantages in regulating tumor immune microenvironment. In this review, we summarize the progress on natural polysaccharides in tumor microenvironment (TME) regulation and the designs of nano-sized drug delivery system, and point out challenges of polysaccharide-based drug delivery systems in the future application, and also give the potential solutions for these issues.

natural polysaccharide  /  nano-sized drug delivery system  /  immunoregulation  /  tumor microenvironment  /  anti-tumor
Tao HAN, Yan CHEN, Ding QU. Research progress of natural polysaccharides and their nano-sized drug delivery systems in regulating tumor microenvironment[J]. Acta Pharmaceutica Sinica, 2021 , 56 (12) : 3212 -3223 . DOI: 10.16438/j.0513-4870.2021-0396
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Article Info
doi: 10.16438/j.0513-4870.2021-0396
  • Receive Date：2021-03-19
  • Online Date：2025-12-18
  • Published：2021-12-12
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  • Received：2021-03-19
  • Revised：2021-05-01
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Affiliations
    1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
    2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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