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A new research paradigm in modernization of traditional Chinese medicine: single cell pharmacology
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Jia-yun CHEN, Qiu-yan GUO, Cheng-chao XU*, Ji-gang WANG*
Acta Pharmaceutica Sinica | 2021, 56(12) : 3300 - 3312
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Acta Pharmaceutica Sinica | 2021, 56(12): 3300-3312
• Special Reports Ⅱ: Biosynthesis of Plant Natural Products and Synthetic Biology for Their Production •
A new research paradigm in modernization of traditional Chinese medicine: single cell pharmacology
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Jia-yun CHEN, Qiu-yan GUO, Cheng-chao XU*, Ji-gang WANG*
Affiliations
  • Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Published: 2021-12-12 doi: 10.16438/j.0513-4870.2021-1010
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Single cell "omics" technology enables the capture of genome, transcriptome, proteome and other omics information in a high-throughput and unbiased manner at single-cell resolution, allowing the characterization of the functional state of individual cells to reveal their heterogeneity and differential responses to drug treatment. This technology has wide application in pharmacological research, facilitating drug screening, efficacy evaluation, and mechanistic studies. We envision that, in the field of traditional Chinese medicine (TCM), single cell omics technology can be applied in the identification of active ingredients and drug targets, and elucidation of drug mechanism of action. In this article, we briefly introduce the single cell omics technology - particularly single cell transcriptome sequencing, and review its application in the field of modern drug research. Based on that, we propose the concept of "single cell pharmacology" and articulate how it can be applied to transform the pharmacological research of TCM and promote TCM modernization.

single cell pharmacology  /  single cell omics technology  /  modernization of traditional Chinese medicine
Jia-yun CHEN, Qiu-yan GUO, Cheng-chao XU, Ji-gang WANG. A new research paradigm in modernization of traditional Chinese medicine: single cell pharmacology[J]. Acta Pharmaceutica Sinica, 2021 , 56 (12) : 3300 -3312 . DOI: 10.16438/j.0513-4870.2021-1010
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Year 2021 volume 56 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2021-1010
  • Receive Date：2021-07-09
  • Online Date：2025-12-18
  • Published：2021-12-12
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  • Received：2021-07-09
  • Accepted：2021-08-11
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    Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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