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Anti-tumor nanoscale drug delivery systems based on photodynamic therapy
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Xue-li JIA1, Yi-jing LIU1, 2, Miao LI1, Li-na DU1, 2, *, Yi-guang JIN1, *
Acta Pharmaceutica Sinica | 2021, 56(12) : 3421 - 3430
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Acta Pharmaceutica Sinica | 2021, 56(12): 3421-3430
• Reviews •
Anti-tumor nanoscale drug delivery systems based on photodynamic therapy
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Xue-li JIA1, Yi-jing LIU1, 2, Miao LI1, Li-na DU1, 2, *, Yi-guang JIN1, *
Affiliations
  • 1. Beijing Institute of Radiation Medicine, Beijing 100850, China
  • 2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
Published: 2021-12-12 doi: 10.16438/j.0513-4870.2021-0371
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Photodynamic therapy (PDT) is a therapeutic strategy by which photosensitizers are excited by specific light irradiation to produce singlet oxygen for killing the surrounding cells. The advantages of PDT include weak invasion, slight side effect, and low resistance. The advantages of nanoscale drug delivery systems (DDS) include tumor-targeting, sustained release, and environmental-sensitivity. The combination of PDT and nanoscale DDS would likely lead to tumor targeting of photosensitizers and enhance their antitumor effectiveness. This review discusses the mechanism of PDT, photosensitizer-loaded nanoscale formulations, the combination of PDT and other antitumor therapies, and summarizes the applications and prospects of anti-tumor nanoscale DDS based on PDT. This review is a useful reference for its clinical application.

photodynamic therapy  /  photosensitizer  /  tumor-targeting  /  nanocarrier  /  combinational therapy
Xue-li JIA, Yi-jing LIU, Miao LI, Li-na DU, Yi-guang JIN. Anti-tumor nanoscale drug delivery systems based on photodynamic therapy[J]. Acta Pharmaceutica Sinica, 2021 , 56 (12) : 3421 -3430 . DOI: 10.16438/j.0513-4870.2021-0371
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Year 2021 volume 56 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2021-0371
  • Receive Date：2021-03-15
  • Online Date：2025-12-18
  • Published：2021-12-12
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History
  • Received：2021-03-15
  • Revised：2021-04-22
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Affiliations
    1. Beijing Institute of Radiation Medicine, Beijing 100850, China
    2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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