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Biopathway construction of plant natural products
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Xiu-yu LIU1, 2, Ling-long LUO1, Ying MA1, Jun-ling BU1, Zhi-min HU1, Shu-fu SUN1, 3, Guang-hong CUI1, Jin-fu TANG1, Juan GUO1, *, Lu-qi HUANG1, *
Acta Pharmaceutica Sinica | 2021, 56(12) : 3285 - 3299
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Acta Pharmaceutica Sinica | 2021, 56(12): 3285-3299
• Special Reports Ⅱ: Biosynthesis of Plant Natural Products and Synthetic Biology for Their Production •
Biopathway construction of plant natural products
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Xiu-yu LIU1, 2, Ling-long LUO1, Ying MA1, Jun-ling BU1, Zhi-min HU1, Shu-fu SUN1, 3, Guang-hong CUI1, Jin-fu TANG1, Juan GUO1, *, Lu-qi HUANG1, *
Affiliations
  • 1. State Key Laboratory of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 2. School of Pharmaceutical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 3. School of Pharmaceutical Sciences, Anhui University of Chinese Medicine, Hefei 230071, China
Published: 2021-12-12 doi: 10.16438/j.0513-4870.2021-1637
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Plant natural products (PNPs) are important sources of innovative drugs. They are mainly obtained by isolation or extraction from plants. Low content and with structural analogues in plants result in high production cost, which restricts the research and application of PNPs. While biopathway construction by synthetic biology provides an alternative for production of PNPs. By biosynthetic pathway analysis of PNPs and reconstructing the biopathway in microorganisms, we can produce PNPs in cell factories efficiently. Recently, several predominantly international reports about biosynthesis of PNPs and its synthetic biology production, triggered the researches of PNPs. Abundant traditional Chinese medicine resources and profound cultural heritage of Chinese medicine make biosynthesis pathway analysis of PNPs to be a research hotspot. And some of the studies have achieved significant progress. Here, recent progress in the biosynthesis of plant natural products and its synthetic biology was reviewed. In particular, the application of new methods and technologies in recent years were summarized and discussed. This will provide reference for the biopathway construction of plant natural products.

plant natural product  /  post-modification enzyme  /  biosynthetic pathway  /  synthetic biology
Xiu-yu LIU, Ling-long LUO, Ying MA, Jun-ling BU, Zhi-min HU, Shu-fu SUN, Guang-hong CUI, Jin-fu TANG, Juan GUO, Lu-qi HUANG. Biopathway construction of plant natural products[J]. Acta Pharmaceutica Sinica, 2021 , 56 (12) : 3285 -3299 . DOI: 10.16438/j.0513-4870.2021-1637
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Year 2021 volume 56 Issue 12
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Article Info
doi: 10.16438/j.0513-4870.2021-1637
  • Receive Date：2021-11-15
  • Online Date：2025-12-18
  • Published：2021-12-12
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History
  • Received：2021-11-15
  • Revised：2021-12-09
Funding
Affiliations
    1. State Key Laboratory of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
    2. School of Pharmaceutical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
    3. School of Pharmaceutical Sciences, Anhui University of Chinese Medicine, Hefei 230071, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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