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Bacterial outer membrane vesicles: a new approach to diseases therapy
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Xiao-han QIU1, 2, 3, 4, Yong-jiang LI1, 3, 4, Jun-yong WU1, 3, 4, Jia-xin CAI1, 3, 4, Ji-hua LIU1, 3, 4, Wen-jie XU1, 3, 4, Da-xiong XIANG1, 3, 4, *
Acta Pharmaceutica Sinica | 2021, 56(12) : 3441 - 3450
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Acta Pharmaceutica Sinica | 2021, 56(12): 3441-3450
• Reviews •
Bacterial outer membrane vesicles: a new approach to diseases therapy
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Xiao-han QIU1, 2, 3, 4, Yong-jiang LI1, 3, 4, Jun-yong WU1, 3, 4, Jia-xin CAI1, 3, 4, Ji-hua LIU1, 3, 4, Wen-jie XU1, 3, 4, Da-xiong XIANG1, 3, 4, *
Affiliations
  • 1. Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China
  • 2. Department of Pharmacy, The First Affiliated Hospital of Hunan University of Medicine, Huaihua 418000, China
  • 3. Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug, Changsha 410011, China
  • 4. Institute of Clinical Pharmacy, Central South University, Changsha 410011, China
Published: 2021-12-12 doi: 10.16438/j.0513-4870.2021-0650
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Outer membrane vesicles (OMVs) are nano-sized spherical vehicles, with a size range between 20-250 nm. OMVs are spontaneously secreted from Gram-negative bacteria and formed by lipid bilayer membranes, comprising multiple parent bacteria-derived components including bacterial antigens, pathogen-associated molecular patterns, proteins and lipids. OMVs have shown multiple potentials for the treatment of various diseases, including cancer therapy and bacterial infection. In this review, the structure, composition and methods for isolating and characterizing of OMVs were introduced. The applications of OMVs for diseases therapy were summarized and future perspectives were discussed.

outer membrane vesicle  /  nanoparticle  /  vaccine  /  cancer immunotherapy  /  drug delivery vehicle
Xiao-han QIU, Yong-jiang LI, Jun-yong WU, Jia-xin CAI, Ji-hua LIU, Wen-jie XU, Da-xiong XIANG. Bacterial outer membrane vesicles: a new approach to diseases therapy[J]. Acta Pharmaceutica Sinica, 2021 , 56 (12) : 3441 -3450 . DOI: 10.16438/j.0513-4870.2021-0650
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Article Info
doi: 10.16438/j.0513-4870.2021-0650
  • Receive Date：2021-04-29
  • Online Date：2025-12-18
  • Published：2021-12-12
Article Data
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History
  • Received：2021-04-29
  • Revised：2021-06-15
Funding
Affiliations
    1. Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha 410011, China
    2. Department of Pharmacy, The First Affiliated Hospital of Hunan University of Medicine, Huaihua 418000, China
    3. Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug, Changsha 410011, China
    4. Institute of Clinical Pharmacy, Central South University, Changsha 410011, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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