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Study on alkaloid constituents of Stephania tetrandra S. Moore
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Da-hai HE1, Jun LIU2, Dong-mei FANG3, *, Xiao-ling WANG1, Li-mei LI1, *
Acta Pharmaceutica Sinica | 2021, 56(12) : 3503 - 3510
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Acta Pharmaceutica Sinica | 2021, 56(12): 3503-3510
• Original Articles •
Study on alkaloid constituents of Stephania tetrandra S. Moore
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Da-hai HE1, Jun LIU2, Dong-mei FANG3, *, Xiao-ling WANG1, Li-mei LI1, *
Affiliations
  • 1. College of Pharmacy, Southwest Minzu University, Chengdu 610041, China
  • 2. College of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China
  • 3. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
Published: 2021-12-12 doi: 10.16438/j.0513-4870.2021-1170
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Fifteen alkaloid compounds were isolated from the 70% aqueous alcohol extract of Stephania tetrandra S. Moore by silica gel, reversed phase silica gel, Sephadex LH-20 column chromatography and semi-preparative high performance liquid chromatography. They were identified as tetrandraside A (1), (Z)-N-formyl-nornuciferin (2), (E)-N-formyl-nornuciferin (3), salutaridine (4), salutaridine N-oxide (5), (E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2 propenamide (6), dauriporphine (7), sinomenine (8), liriodenine (9), α-magnoflorine (10), (1S)-4'-β-glucosylcoclaurine (11), tetrandrine (12), fangchinoline (13), tetrandrine 2'-β-oxide (14), and tetrandrine 2'-α-oxide (15), respectively, by MS, NMR and single crystal diffraction. Among them, compound 1 is a new alkaloid glycoside. Compounds 2-11 were obtained from this plant for the first time. These compounds showed obvious cytotoxic activity against drug-resistant lung cancer cell line H1299, and compound 9 had the best activity, with an IC50 of 5.38 μmol·L-1.

Stephania tetrandra  /  alkaloid  /  X-ray diffraction  /  tetrandraside A
Da-hai HE, Jun LIU, Dong-mei FANG, Xiao-ling WANG, Li-mei LI. Study on alkaloid constituents of Stephania tetrandra S. Moore[J]. Acta Pharmaceutica Sinica, 2021 , 56 (12) : 3503 -3510 . DOI: 10.16438/j.0513-4870.2021-1170
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doi: 10.16438/j.0513-4870.2021-1170
  • Receive Date：2021-08-11
  • Online Date：2025-12-18
  • Published：2021-12-12
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History
  • Received：2021-08-11
  • Revised：2021-09-02
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Affiliations
    1. College of Pharmacy, Southwest Minzu University, Chengdu 610041, China
    2. College of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China
    3. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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