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Ginkgo biloba extract ameliorates streptozotocin-induced diabetes in rats as measured by non-targeted metabolomics
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Fan ZHANG1, Xun-xiu HU1, Ding-xiang LI1, Ran ZHANG1, Lin-lin ZHAO1, Yan DU1, Dao-quan TANG1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(4) : 1127 - 1136
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Acta Pharmaceutica Sinica | 2021, 56(4): 1127-1136
• Original Articles •
Ginkgo biloba extract ameliorates streptozotocin-induced diabetes in rats as measured by non-targeted metabolomics
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Fan ZHANG1, Xun-xiu HU1, Ding-xiang LI1, Ran ZHANG1, Lin-lin ZHAO1, Yan DU1, Dao-quan TANG1, 2, *
Affiliations
  • 1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
  • 2. Department of Pharmaceutical Analysis, Xuzhou Medical University, Xuzhou 221004, China
Published: 2021-04-12 doi: 10.16438/j.0513-4870.2021-0064
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Metabolomics based on liquid chromatography coupled with mass spectrometry (LC-MS) was used to study the initiation and development of diabetes in rats, and the ability of Ginkgo biloba extract (GBE) to ameliorate this pathology. Diabetes mellitus (DM) was induced by intra-peritoneal injection of streptozotocin. The rats were randomly divided into a normal control group treated with drug-free solution (NC), a normal control group treated with GBE (N-GBE), a DM group treated with drug-free solution (DM), and a DM group treated with GBE (D-GBE); rats were maintained on this protocol for 9 weeks. Rat plasma was collected from the sixth week to the ninth week and then analyzed with LC-MS. Animal experimentation was approved by the Committee on the Ethics of Animal Experiments of Xuzhou Medical University. Twelve plasma metabolites with continuous differentiation were monitored to indicate dysfunction of metabolic pathways including fatty acid metabolism, phospholipid metabolism, amino acid metabolism, tricarboxylic acid cycle activity, bile acid metabolism, and purine metabolism to confirm the occurrence and development of DM. Treatment with GBE partially reversed the changes seen in five metabolites in DM rats, indicating that GBE could prevent the occurrence and development of DM by acting on fatty acid metabolism, phospholipid metabolism, amino acid metabolism, and the tricarboxylic acid cycle.

diabetes mellitus  /  metabolomics  /  plasma  /  Ginkgo biloba leaves extract  /  LC-MS
Fan ZHANG, Xun-xiu HU, Ding-xiang LI, Ran ZHANG, Lin-lin ZHAO, Yan DU, Dao-quan TANG. Ginkgo biloba extract ameliorates streptozotocin-induced diabetes in rats as measured by non-targeted metabolomics[J]. Acta Pharmaceutica Sinica, 2021 , 56 (4) : 1127 -1136 . DOI: 10.16438/j.0513-4870.2021-0064
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Year 2021 volume 56 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2021-0064
  • Receive Date：2021-01-14
  • Online Date：2025-12-18
  • Published：2021-04-12
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  • Received：2021-01-14
  • Revised：2021-02-24
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Affiliations
    1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
    2. Department of Pharmaceutical Analysis, Xuzhou Medical University, Xuzhou 221004, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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