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Research progress on the antitumor effect of flavonoid derivatives
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Xin-ping LI1, Mei-xuan YU1, Ting-rui KUANG1, Xi YAN1, *, Chun-ying LI2, *, Hai-jun HAO3, *
Acta Pharmaceutica Sinica | 2021, 56(4) : 913 - 923
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Acta Pharmaceutica Sinica | 2021, 56(4): 913-923
• Reviews •
Research progress on the antitumor effect of flavonoid derivatives
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Xin-ping LI1, Mei-xuan YU1, Ting-rui KUANG1, Xi YAN1, *, Chun-ying LI2, *, Hai-jun HAO3, *
Affiliations
  • 1. College of Chemistry, Beijing Normal University, Beijing 100875, China
  • 2. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
  • 3. Department of Organic Chemistry, College of Science, Beijing University of Chemical Technology, Beijing 100029, China
Published: 2021-04-12 doi: 10.16438/j.0513-4870.2020-1296
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Malignant tumors seriously endanger human life and health, and their treatment has always been a research focus of scientists all over the world. Natural flavonoids and their derivatives have a variety of biological activities, especially regarding antitumor growth, with unique biological activities. They can interfere with the growth cycle of tumor cells, change the mitochondrial membrane potential, promote apoptosis, and can reduce the immune escape of tumor cells and prevent tumor metastasis by improving human immunity. In the human body, they regulate the biological signal transduction, leading to the up-regulation of pro-apoptotic protein expression. They inhibit the growth of solid tumors by regulating the growth of vascular epithelial cells and blocking the formation of blood vessels in tumor tissue. Recent studies have shown that these compounds can play an important role in the treatment of various human tumors and are expected to be developed into new antitumor drugs. This review summarizes the recent research results on the antitumor mechanism of flavonoids and their ability to inhibit tumor growth.

flavonoid  /  cancer  /  antitumor  /  plant  /  mechanism
Xin-ping LI, Mei-xuan YU, Ting-rui KUANG, Xi YAN, Chun-ying LI, Hai-jun HAO. Research progress on the antitumor effect of flavonoid derivatives[J]. Acta Pharmaceutica Sinica, 2021 , 56 (4) : 913 -923 . DOI: 10.16438/j.0513-4870.2020-1296
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Article Info
doi: 10.16438/j.0513-4870.2020-1296
  • Receive Date：2020-08-07
  • Online Date：2025-12-18
  • Published：2021-04-12
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History
  • Received：2020-08-07
  • Revised：2020-08-24
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Affiliations
    1. College of Chemistry, Beijing Normal University, Beijing 100875, China
    2. Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    3. Department of Organic Chemistry, College of Science, Beijing University of Chemical Technology, Beijing 100029, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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