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Research progress in tumor microenvironmentally modulating nanostructures
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Cai-xia SUN1, Yan-min JU2, *, Jian-jun DAI1, 2
Acta Pharmaceutica Sinica | 2021, 56(4) : 1016 - 1024
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Acta Pharmaceutica Sinica | 2021, 56(4): 1016-1024
• Reviews •
Research progress in tumor microenvironmentally modulating nanostructures
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Cai-xia SUN1, Yan-min JU2, *, Jian-jun DAI1, 2
Affiliations
  • 1. School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China
  • 2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Published: 2021-04-12 doi: 10.16438/j.0513-4870.2020-1572
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Tumor microenvironment (TME) is a complex comprehensive system composed of immune cells, inflammatory cells, tumor-associated fibroblasts, microvessels, and various cytokines and chemokines. As the living environment of tumor cells, it's closely related to the occurrence, metastasis, and recurrence of tumors. The characteristics of tumor microenvironment include: weakly acidic environment, low oxygen, high concentration of reactive oxygen species (ROS) and reducing substances, immunosuppression, etc. A weakly acidic environment favors metastasis of tumor cells, hypoxia is conducive to the emergence of drug resistance, high concentration of ROS and reducing substances are beneficial for tumor treatment, and immunosuppressiveness facilitates immune escape. With the rapid development of nanotechnology, more and more nanostructures have been reported to achieve tumor treatment by regulating the tumor microenvironment. This review summarizes recent advances in the nanostructures used to regulate tumor microenvironment through changing elements, including hydrogen-ion concentration (pH), the concentration of oxygen (O2) and reactive oxygen species, and the activity of immune cells. Moreover, research directions in the future are pointed out in this review.

nanostructure  /  tumor microenvironment  /  hydrogen-ion concentration  /  oxygen  /  reactive oxygen species  /  immunosuppression
Cai-xia SUN, Yan-min JU, Jian-jun DAI. Research progress in tumor microenvironmentally modulating nanostructures[J]. Acta Pharmaceutica Sinica, 2021 , 56 (4) : 1016 -1024 . DOI: 10.16438/j.0513-4870.2020-1572
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Year 2021 volume 56 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2020-1572
  • Receive Date：2020-09-30
  • Online Date：2025-12-18
  • Published：2021-04-12
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History
  • Received：2020-09-30
  • Revised：2020-10-15
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Affiliations
    1. School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China
    2. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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