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The mechanism of action of Pudilan Xiaoyan oral liquid against LPS-induced acute respiratory infection in mice based on biological network analysis and metabolomics
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Gang TIAN1, Yuan-zhuo HU2, Chao LI1, Yuan-yuan ZHAI2, Bei-hua BAO2, Wei-feng YAO2, *, Li ZHANG2, An-wei DING2
Acta Pharmaceutica Sinica | 2021, 56(3) : 816 - 822
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Acta Pharmaceutica Sinica | 2021, 56(3): 816-822
• Original Articles •
The mechanism of action of Pudilan Xiaoyan oral liquid against LPS-induced acute respiratory infection in mice based on biological network analysis and metabolomics
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Gang TIAN1, Yuan-zhuo HU2, Chao LI1, Yuan-yuan ZHAI2, Bei-hua BAO2, Wei-feng YAO2, *, Li ZHANG2, An-wei DING2
Affiliations
  • 1. Jumpcan Pharmaceutical Co., Ltd., Taizhou 225411, China
  • 2. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
Published: 2021-03-12 doi: 10.16438/j.0513-4870.2020-1585
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This study integrates metabolomics and network pharmacology techniques to systematically analyze the possible mechanism of Pudilan Xiaoyan oral liquid (PDL) in the treatment of acute respiratory infections. GC-MS metabolomics analysis found 8 endogenous metabolites, 3-phosphoglycerate, α-aminoadipate, D-ribulose-5-phosphate, β-mannosylglyceric acid, D-fructose, urea, D-maltose and ornithine in the serum of mice with acute respiratory infection induced by LPS; these substances can be used as biomarkers for PDL use in the treatment of acute respiratory infections. Biological network studies revealed 10 potential targets for intervention by PDL in the glycolysis and pentose phosphate pathways, including GPI, G6PD, H6PD, PFKM, TALDO1, TKT, GAPDH, HK1, PKLR and TPI1. All animal experiments were carried out with approval of the Animal Ethics Committee of Nanjing University of Chinese Medicine. Our findings indicate that the strategy of combining metabolomics and network analysis can provide information on the possible mechanism of PDL in acute respiratory infections, and reveal that PDL may ameliorate the pathological process of acute respiratory infections by regulating disordered metabolic pathways.

Pudilan Xiaoyan oral liquid  /  network pharmacology  /  metabolomics  /  LPS  /  acute respiratory infection
田刚, 胡远卓, 李超, 翟园园, 包贝华, 姚卫峰, 张丽, 丁安伟. 基于生物网络和代谢组学研究蒲地蓝消炎口服液抗LPS诱导小鼠急性呼吸道感染的作用机制. 药学学报, 2021 , 56 (3) : 816 -822 . DOI: 10.16438/j.0513-4870.2020-1585
Gang TIAN, Yuan-zhuo HU, Chao LI, Yuan-yuan ZHAI, Bei-hua BAO, Wei-feng YAO, Li ZHANG, An-wei DING. The mechanism of action of Pudilan Xiaoyan oral liquid against LPS-induced acute respiratory infection in mice based on biological network analysis and metabolomics[J]. Acta Pharmaceutica Sinica, 2021 , 56 (3) : 816 -822 . DOI: 10.16438/j.0513-4870.2020-1585
Appendix
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Year 2021 volume 56 Issue 3
874
282
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Article Info
doi: 10.16438/j.0513-4870.2020-1585
  • Receive Date：2020-10-05
  • Online Date：2025-12-18
  • Published：2021-03-12
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History
  • Received：2020-10-05
  • Revised：2020-12-02
Funding
Affiliations
    1. Jumpcan Pharmaceutical Co., Ltd., Taizhou 225411, China
    2. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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