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Development and application of a chemical transformational method for the indirect measurement of ligustilide content in Angelica sinensis
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Peng-cheng WU1, 2, Pan ZHAO1, Xing-ping LUO3, Yun-jie WANG4, Xiao-ning WEI1, Quan HAO4, Peng-wei LIU5, Rui-li LIN6, Lin NI6, Ping-shun SONG6, *, Jun-xi LIU1, *
Acta Pharmaceutica Sinica | 2021, 56(3) : 841 - 848
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Acta Pharmaceutica Sinica | 2021, 56(3): 841-848
• Original Articles •
Development and application of a chemical transformational method for the indirect measurement of ligustilide content in Angelica sinensis
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Peng-cheng WU1, 2, Pan ZHAO1, Xing-ping LUO3, Yun-jie WANG4, Xiao-ning WEI1, Quan HAO4, Peng-wei LIU5, Rui-li LIN6, Lin NI6, Ping-shun SONG6, *, Jun-xi LIU1, *
Affiliations
  • 1. Chinese Academy of Sciences Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
  • 2. University of Chinese Academy of Sciences, Beijing 100049, China
  • 3. School of Chemical Engineering, Northwest Minzu University, Lanzhou 730030, China
  • 4. Lanzhou Foci Pharmaceutical CO., LTD, Lanzhou 730046, China
  • 5. Minxian Institute of Angelica sinensis of Gansu Province, Dingxi 748400, China
  • 6. Gansu Institute for Drug Control, Lanzhou 730000, China
Published: 2021-03-12 doi: 10.16438/j.0513-4870.2020-1484
Outline
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The poor stability of the ligustilide (LIG) makes its quantitation in Angelica sinensis (AS) difficult. This study establishes a chemical conversion method for the determination of ligustilide content in AS and proposes a national pharmacopoeia standard. Mechanical agitation and sonication of a powdered AS extract in a methanol/cyprolamine mixture facilitated the stabilization and transformation of ligustilide. Using an external reference HPLC-DAD method, the cyclopropyl-ligustilide (LIGc) content in the mixture could be determined. The content of ligustilide was greater than 1.0% based on 144 AS specimens including 68 obtained from the originally planted areas of Qinghai and Gansu Province; 55 specimens were obtained from Minxian and Weiyuan County medicine markets, and 21 specimens for which the storage period reached or exceeded 1.5 years. According to the Hong Kong Chinese materis medica standards, the content of ligustilide in AS should not be lower than 0.6%. The developed method could also be applied to the quality control of other Chinese medicinal materials (such as Ligusticum chuanxiong) or Chinese patent medicines in which ligustilide is the main component.

ligustilide  /  chemical conversion  /  quality standard  /  Angelica sinensis  /  liquid chromatography
Peng-cheng WU, Pan ZHAO, Xing-ping LUO, Yun-jie WANG, Xiao-ning WEI, Quan HAO, Peng-wei LIU, Rui-li LIN, Lin NI, Ping-shun SONG, Jun-xi LIU. Development and application of a chemical transformational method for the indirect measurement of ligustilide content in Angelica sinensis[J]. Acta Pharmaceutica Sinica, 2021 , 56 (3) : 841 -848 . DOI: 10.16438/j.0513-4870.2020-1484
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Year 2021 volume 56 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2020-1484
  • Receive Date：2020-09-15
  • Online Date：2025-12-18
  • Published：2021-03-12
Article Data
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History
  • Received：2020-09-15
  • Revised：2020-12-08
Funding
Affiliations
    1. Chinese Academy of Sciences Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
    2. University of Chinese Academy of Sciences, Beijing 100049, China
    3. School of Chemical Engineering, Northwest Minzu University, Lanzhou 730030, China
    4. Lanzhou Foci Pharmaceutical CO., LTD, Lanzhou 730046, China
    5. Minxian Institute of Angelica sinensis of Gansu Province, Dingxi 748400, China
    6. Gansu Institute for Drug Control, Lanzhou 730000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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