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Current status of treatment and drug discovery for neuropathic pain
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Jia-nan SONG1, 2, Hai-bo YU2, *, Yu-mei LIU1, *
Acta Pharmaceutica Sinica | 2021, 56(3) : 679 - 688
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Acta Pharmaceutica Sinica | 2021, 56(3): 679-688
• Reviews •
Current status of treatment and drug discovery for neuropathic pain
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Jia-nan SONG1, 2, Hai-bo YU2, *, Yu-mei LIU1, *
Affiliations
  • 1. Department of Neurobiology, Harbin Medical University, Harbin 150086, China
  • 2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2021-03-12 doi: 10.16438/j.0513-4870.2020-1131
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Neuropathic pain (NP) is a medical problem that has been bothering human beings and seriously affects people's quality of life. Although great progress has been made in the study of NP in recent years, there are still many patients who are ineffective to the existing treatments. At present, drug therapy is still the main method to relieve pain, however, adverse drug reactions has hindered the curative effects of drugs. It is extremely urgent to find new drug targets and reduce the adverse effects of existing drugs. This review will mainly describe the current situation and pathogenesis of neuropathic pain, effectiveness and limitations of existing drugs for treating neuropathic pain, and the current status of drug discovery.

neuropathic pain  /  pharmacological treatment  /  ion channel  /  G-protein coupled receptor  /  drug discovery
Jia-nan SONG, Hai-bo YU, Yu-mei LIU. Current status of treatment and drug discovery for neuropathic pain[J]. Acta Pharmaceutica Sinica, 2021 , 56 (3) : 679 -688 . DOI: 10.16438/j.0513-4870.2020-1131
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Article Info
doi: 10.16438/j.0513-4870.2020-1131
  • Receive Date：2020-07-08
  • Online Date：2025-12-18
  • Published：2021-03-12
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History
  • Received：2020-07-08
  • Revised：2020-08-20
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Affiliations
    1. Department of Neurobiology, Harbin Medical University, Harbin 150086, China
    2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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