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Research progress of neutrophil extracellular traps and related targeted drugs for the treatment of inflammatory diseases
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Yan DING, Jiao QU, Yang SUN*
Acta Pharmaceutica Sinica | 2021, 56(3) : 669 - 678
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Acta Pharmaceutica Sinica | 2021, 56(3): 669-678
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Research progress of neutrophil extracellular traps and related targeted drugs for the treatment of inflammatory diseases
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Yan DING, Jiao QU, Yang SUN*
Affiliations
  • State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, China
Published: 2021-03-12 doi: 10.16438/j.0513-4870.2020-1673
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The inflammatory response is an essential role of innate immune cells such as neutrophils, which plays an important role in the occurrence and development of inflammatory diseases. Neutrophil extracellular traps (NETs) are responsible for killing microorganisms and inducing the inflammatory response. We review the function of NETs in inflammatory diseases based on research publications since 2016. In addition, the ability of drugs that target NETs to ameliorate inflammation-related diseases is summarized. This review suggests a new strategy of targeting NETs for the treatment of inflammation-related diseases.

neutrophil extracellular trap  /  inflammatory disease  /  inflammation  /  targeting therapy
Yan DING, Jiao QU, Yang SUN. Research progress of neutrophil extracellular traps and related targeted drugs for the treatment of inflammatory diseases[J]. Acta Pharmaceutica Sinica, 2021 , 56 (3) : 669 -678 . DOI: 10.16438/j.0513-4870.2020-1673
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Year 2021 volume 56 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2020-1673
  • Receive Date：2020-10-26
  • Online Date：2025-12-18
  • Published：2021-03-12
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History
  • Received：2020-10-26
  • Revised：2020-11-24
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Affiliations
    State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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