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Review of novel compounds that act on the AT2 receptor
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Yan-chun ZHANG1, 2, *, Zu-zhi ZHANG1, Jin-yi XU3, Dan-hui WANG1, Mei-yue XU1
Acta Pharmaceutica Sinica | 2021, 56(3) : 711 - 722
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Acta Pharmaceutica Sinica | 2021, 56(3): 711-722
• Reviews •
Review of novel compounds that act on the AT2 receptor
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Yan-chun ZHANG1, 2, *, Zu-zhi ZHANG1, Jin-yi XU3, Dan-hui WANG1, Mei-yue XU1
Affiliations
  • 1. College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
  • 2. Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei 230012, China
  • 3. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Published: 2021-03-12 doi: 10.16438/j.0513-4870.2020-1389
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Selective activation or inhibition of the angiotensin Ⅱ type 2 (AT2) receptor can cause vasodilation, decrease cell proliferation, promote neurite outgrowth and block neuronal excitability. The AT2 receptor can be used as a potential drug target for the treatment of cardiovascular diseases, fibrosis, inflammation, neuronal diseases and tumors. Research and development of new drugs that selectively act on the AT2 receptor and the mechanism of intracellular signal transduction involving the AT2 receptor is a challenging but worthy endeavor. We review research progress on the AT2 receptor and compounds that act on the AT2 receptor, along with structure-activity relationship analysis, to provide reference and guidance for further research in this field.

angiotensin receptor type 2 receptor  /  agonist  /  antagonist  /  selectivity  /  structure and activity relationship
Yan-chun ZHANG, Zu-zhi ZHANG, Jin-yi XU, Dan-hui WANG, Mei-yue XU. Review of novel compounds that act on the AT2 receptor[J]. Acta Pharmaceutica Sinica, 2021 , 56 (3) : 711 -722 . DOI: 10.16438/j.0513-4870.2020-1389
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Year 2021 volume 56 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2020-1389
  • Receive Date：2020-08-24
  • Online Date：2025-12-18
  • Published：2021-03-12
Article Data
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History
  • Received：2020-08-24
  • Revised：2020-09-23
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Affiliations
    1. College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
    2. Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei 230012, China
    3. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
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