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Research progress on the interaction of neuropsychiatric drugs with the gut microbiota
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Zheng-wei ZHANG1, Zhen-xiong ZHAO1, 2, Yan WANG1, *, Jian-dong JIANG1, *
Acta Pharmaceutica Sinica | 2021, 56(3) : 643 - 653
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Acta Pharmaceutica Sinica | 2021, 56(3): 643-653
• Professionals Forum •
Research progress on the interaction of neuropsychiatric drugs with the gut microbiota
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Zheng-wei ZHANG1, Zhen-xiong ZHAO1, 2, Yan WANG1, *, Jian-dong JIANG1, *
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. The Affiliated Tumor Hospital of Shandong First Medical University, Jinan 250024, China
Published: 2021-03-12 doi: 10.16438/j.0513-4870.2020-1516
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The gut microbiota is an intricate and dynamic community composed of many symbiotic and pathogenic microorganisms, and works closely with the host. In recent years increasing evidence has supported the gut-brain axis theory, lending support for a link between gut microbiota and neuropsychiatric diseases. Since most of the drugs used to treat neuropsychiatric diseases enter the intestinal tract after oral administration, interaction with the gut microbiota is likely. A number of studies have shown that such drugs can change the composition and function of the gut microbiota. At the same time, the gut microbiota also participates in the metabolism of drugs, which in turn have beneficial or harmful effects on brain function. Therefore, the role of gut microbiota in drug metabolism also has attracted attention. This article reviews the research results of the interaction between the two, discusses the influence of neuropsychiatric diseases on the gut microbiota and the effect of the gut microbiota on psychoactive drugs, and provides new ideas for the treatment of various clinical neuropsychiatric diseases.

gut microbiota  /  neuropsychiatric disease  /  drug metabolism  /  gut-brain axis  /  interaction
Zheng-wei ZHANG, Zhen-xiong ZHAO, Yan WANG, Jian-dong JIANG. Research progress on the interaction of neuropsychiatric drugs with the gut microbiota[J]. Acta Pharmaceutica Sinica, 2021 , 56 (3) : 643 -653 . DOI: 10.16438/j.0513-4870.2020-1516
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Year 2021 volume 56 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2020-1516
  • Receive Date：2020-09-29
  • Online Date：2025-12-18
  • Published：2021-03-12
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History
  • Received：2020-09-29
  • Revised：2020-12-24
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Affiliations
    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. The Affiliated Tumor Hospital of Shandong First Medical University, Jinan 250024, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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