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Research advances on the protective effects and mechanism of salvianolic acids against ischemic heart disease
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Awaguli DAWUTI, Lian-hua FANG*, Guan-hua DU*
Acta Pharmaceutica Sinica | 2021, 56(2) : 368 - 373
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Acta Pharmaceutica Sinica | 2021, 56(2): 368-373
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Research advances on the protective effects and mechanism of salvianolic acids against ischemic heart disease
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Awaguli DAWUTI, Lian-hua FANG*, Guan-hua DU*
Affiliations
  • Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2021-02-12 doi: 10.16438/j.0513-4870.2020-1277
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Salvianolic acids are the main water-soluble active compounds of Salvia miltiorrhiza and have been widely used for the treatment of cardiovascular diseases. Based on the latest studies in China and abroad, we summarize the pharmacological effects and mechanism of salvianolic acids on ischemic heart disease by describing how salvianolic acid A and salvianolic acid B protect the vascular endothelium, relax coronary arteries, promote angiogenesis and anti-platelet aggregation, inhibit the inflammatory response, anti-cell apoptosis, and scavenge free radicals. This review provides a theoretical basis for further research on the effects of salvianolic acids on ischemic heart disease and their potential for drug development.

Salvia miltiorrhiza  /  water-soluble component  /  salvianolic acid A  /  salvianolic acid B  /  ischemic heart disease
Awaguli DAWUTI, Lian-hua FANG, Guan-hua DU. Research advances on the protective effects and mechanism of salvianolic acids against ischemic heart disease[J]. Acta Pharmaceutica Sinica, 2021 , 56 (2) : 368 -373 . DOI: 10.16438/j.0513-4870.2020-1277
Year 2021 volume 56 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2020-1277
  • Receive Date:2020-08-01
  • Online Date:2025-12-18
  • Published:2021-02-12
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  • Received:2020-08-01
  • Revised:2020-10-05
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    Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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