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Role of gut microbiota in the treatment of ulcerative colitis with traditional Chinese medicine
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Zhu-ping TAO1, Yu LONG2, Can-wei LI3, Ai-wu YIN4, Meng-ran FAN1, Ying LI1, Wei-hong LIU5, Peng-fei GAO*, 1, 6
Acta Pharmaceutica Sinica | 2021, 56(2) : 391 - 402
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Acta Pharmaceutica Sinica | 2021, 56(2): 391-402
• Reviews •
Role of gut microbiota in the treatment of ulcerative colitis with traditional Chinese medicine
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Zhu-ping TAO1, Yu LONG2, Can-wei LI3, Ai-wu YIN4, Meng-ran FAN1, Ying LI1, Wei-hong LIU5, Peng-fei GAO*, 1, 6
Affiliations
  • 1. College of Pharmacy, Dali University, Dali 671000, China
  • 2. The Second Hospital of Nanhua University, Hengyang 421001, China
  • 3. College of Public Health, Dali University, Dali 671000, China
  • 4. Xiangtan Medicine and Health Vocational College, Xiangtan 411104, China
  • 5. College of Agriculture and Biological Science, Dali University, Dali 671000, China
  • 6. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Dali 671000, China
Published: 2021-02-12 doi: 10.16438/j.0513-4870.2020-1802
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Ulcerative colitis(UC) is a chronic non-specific inflammatory bowel disease, listed as a modern refractory disease by the World Health Organization, which is difficult to recover, whereas it is easy to be attacked repeatedly. UC pathogenesis is closely related to gut microbiota dysbiosis. The gut microbiota interacts with bile acids(BAs), short-chain fatty acids(SCFAs), tryptophan, and other metabolism, immune system, intestinal barrier, etc., which regulate each other and affect the occurrence and development of UC. The active ingredients of traditional Chinese medicine(TCM), single herb and its extracts, and formulae can effectively alleviate UC symptoms by regulating the diversity, structure, composition, and metabolites of gut microbiota. In this review, the TCM based on the regulation of gut microbiota in the treatment of UC and its related mechanism for nearly three years was summarized.

ulcerative colitis  /  gut microbiota  /  mechanism  /  traditional Chinese medicine
Zhu-ping TAO, Yu LONG, Can-wei LI, Ai-wu YIN, Meng-ran FAN, Ying LI, Wei-hong LIU, Peng-fei GAO. Role of gut microbiota in the treatment of ulcerative colitis with traditional Chinese medicine[J]. Acta Pharmaceutica Sinica, 2021 , 56 (2) : 391 -402 . DOI: 10.16438/j.0513-4870.2020-1802
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Article Info
doi: 10.16438/j.0513-4870.2020-1802
  • Receive Date：2020-11-25
  • Online Date：2025-12-18
  • Published：2021-02-12
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History
  • Received：2020-11-25
  • Revised：2020-12-22
Funding
Affiliations
    1. College of Pharmacy, Dali University, Dali 671000, China
    2. The Second Hospital of Nanhua University, Hengyang 421001, China
    3. College of Public Health, Dali University, Dali 671000, China
    4. Xiangtan Medicine and Health Vocational College, Xiangtan 411104, China
    5. College of Agriculture and Biological Science, Dali University, Dali 671000, China
    6. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Dali 671000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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