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Application of natural deep eutectic solvents in pharmaceutics
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Jing-jing XUAN1, 2, Xi-ying WU3, Jian-ping QI4, Jie ZHUANG*, 2, 5
Acta Pharmaceutica Sinica | 2021, 56(1) : 146 - 157
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Acta Pharmaceutica Sinica | 2021, 56(1): 146-157
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Application of natural deep eutectic solvents in pharmaceutics
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Jing-jing XUAN1, 2, Xi-ying WU3, Jian-ping QI4, Jie ZHUANG*, 2, 5
Affiliations
  • 1. Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
  • 3. Shanghai Dermatology Hospital, Shanghai 200443, China
  • 4. School of Pharmacy, Fudan University, Shanghai 201203, China
  • 5. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2021-01-12 doi: 10.16438/j.0513-4870.2020-1148
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Natural deep eutectic solvent(NDES) is a kind of deep eutectic solvents(DESs) which is composed of natural substances with good biocompatibility. Those substances can function as hydrogen bond donor and acceptor, such as choline, amino acids, sugars, etc. NDES have been widely used in many fields due to their advantages of low cost, easy preparation and environmental friendliness. It is especially suitable for the pharmaceutical industry because of its good biocompatibility and safety for use. In this paper, we firstly review the molecular simulation methods for current design of DESs from the formation principle. And then, the materials and preparation of NDES are reviewed and the physicochemical properties are further described. Finally, we review the current application of NDES in pharmaceutics including increasing drug solubility, promoting drug permeability and enhancing oral drug absorption, and meanwhile their future applications in pharmaceutics were also prospected.

natural deep eutectic solvent  /  ionic liquid  /  increasing solubility  /  enhancing permeation  /  drug eutectic
Jing-jing XUAN, Xi-ying WU, Jian-ping QI, Jie ZHUANG. Application of natural deep eutectic solvents in pharmaceutics[J]. Acta Pharmaceutica Sinica, 2021 , 56 (1) : 146 -157 . DOI: 10.16438/j.0513-4870.2020-1148
Year 2021 volume 56 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2020-1148
  • Receive Date:2020-07-09
  • Online Date:2025-12-18
  • Published:2021-01-12
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History
  • Received:2020-07-09
  • Revised:2020-08-07
Affiliations
    1. Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
    3. Shanghai Dermatology Hospital, Shanghai 200443, China
    4. School of Pharmacy, Fudan University, Shanghai 201203, China
    5. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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