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A new polyacetylene from the stems and leaves of Chrysanthemum morifolium Ramat
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Jing-ya SHI1, 2, Meng LI1, 2, Meng-nan CENG1, 2, Jing-ke ZHANG1, 2, Juan-juan LIU1, 2, Deng-hui ZHU1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG*, 1, 2
Acta Pharmaceutica Sinica | 2021, 56(1) : 283 - 288
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Acta Pharmaceutica Sinica | 2021, 56(1): 283-288
• Original Articles •
A new polyacetylene from the stems and leaves of Chrysanthemum morifolium Ramat
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Jing-ya SHI1, 2, Meng LI1, 2, Meng-nan CENG1, 2, Jing-ke ZHANG1, 2, Juan-juan LIU1, 2, Deng-hui ZHU1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG*, 1, 2
Affiliations
  • 1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Published: 2021-01-12 doi: 10.16438/j.0513-4870.2020-1376
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Eight polyacetylenes were isolated from the extract of the stems and leaves of Chrysanthemum morifolium by various chromatographic methods. Their structures were determined as 2E, 4E, 12Z-tetradecatriene-1-pyrrolidine-1-oxo-8,10-diynoic(1), tetradeca-2E, 4E, 12E-trien-8,10-diynoic acid pyrrolidide(2), tetradeca-2E, 4E-dien-8,10-diynoic acid pyrrolidide(3), tetradeca-2E, 4E, 10Z-trien-8-ynoic acid pyrrolidide(4), 2E, 4E, 12E-tetradecatriene-8,10-diynoic acid isobutylamide(5), 2E, 4E-undecyldiene-8,10-diynoic acid isobutylamide(6), 2E, 4E, 10E-N-isobutyl-2,4,10-tetradecatrien-8-ynoic acid amide(7), and undeca-2E, 4E-diene-8,10-diynoic acid phenylethylamide(8) by spectroscopic methods, including UV, IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR spectra.Among them, compound 1 is a new polyacetylene, and compounds 2-8 were isolated from this plant for the first time. Compounds 5-8 inhibited the proliferation of A549 cell significantly at certain concentration, showing potent antitumor activity.

Chrysanthemum morifolium  /  stem and leave  /  chemical constituent  /  polyacetylenes  /  cytotoxicity
Jing-ya SHI, Meng LI, Meng-nan CENG, Jing-ke ZHANG, Juan-juan LIU, Deng-hui ZHU, Xiao-ke ZHENG, Wei-sheng FENG. A new polyacetylene from the stems and leaves of Chrysanthemum morifolium Ramat[J]. Acta Pharmaceutica Sinica, 2021 , 56 (1) : 283 -288 . DOI: 10.16438/j.0513-4870.2020-1376
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Year 2021 volume 56 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2020-1376
  • Receive Date：2020-08-24
  • Online Date：2025-12-18
  • Published：2021-01-12
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History
  • Received：2020-08-24
  • Revised：2020-09-17
Funding
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    1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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