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Analysis of technical difficulties and new strategies of oral liquid pharmaceutical preparation for children
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Xin CHEN1, An LU1, Xiang-yu WANG1, Xiao-ling WANG*, 2, Ai-ping ZHENG3, Jian-cheng WANG*, 1
Acta Pharmaceutica Sinica | 2021, 56(1) : 130 - 137
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Acta Pharmaceutica Sinica | 2021, 56(1): 130-137
• Reviews •
Analysis of technical difficulties and new strategies of oral liquid pharmaceutical preparation for children
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Xin CHEN1, An LU1, Xiang-yu WANG1, Xiao-ling WANG*, 2, Ai-ping ZHENG3, Jian-cheng WANG*, 1
Affiliations
  • 1. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
  • 2. Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
  • 3. Institute of Pharmacology and Toxicology of the Academy of Military Medical Sciences, Beijing 100850, China
Published: 2021-01-12 doi: 10.16438/j.0513-4870.2020-1196
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With the implementation of the two-child policy and the growing demand for child health, pediatric medication has been arousing widespread social concern. To develop the drugs suitable for children, including new compounds, new specifications and new dosage forms, is urgently required for pharmaceutical researchers. In this review, several technical bottlenecks for pediatric oral liquid preparations, as well as the novel strategies involved in drug nanocrystals, self-microemulsion, ion exchange resin and Pickering emulsion were discussed, which may be benefit to play a theoretical guiding role in the research and development of children's oral liquid formulation.

oral drug administration  /  pediatrics  /  liquid pharmaceutical preparation  /  emulsion  /  ion exchange resin
Xin CHEN, An LU, Xiang-yu WANG, Xiao-ling WANG, Ai-ping ZHENG, Jian-cheng WANG. Analysis of technical difficulties and new strategies of oral liquid pharmaceutical preparation for children[J]. Acta Pharmaceutica Sinica, 2021 , 56 (1) : 130 -137 . DOI: 10.16438/j.0513-4870.2020-1196
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Article Info
doi: 10.16438/j.0513-4870.2020-1196
  • Receive Date：2020-07-19
  • Online Date：2025-12-18
  • Published：2021-01-12
Article Data
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History
  • Received：2020-07-19
  • Revised：2020-08-29
Funding
Affiliations
    1. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    2. Beijing Children's Hospital, Capital Medical University, Beijing 100045, China
    3. Institute of Pharmacology and Toxicology of the Academy of Military Medical Sciences, Beijing 100850, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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