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Challenges in the study of self-assembled aggregates in decoction of traditional Chinese medicine: A preliminary review
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Qi WANG1, 2, Xiao-meng GUO1, 2, Qian-kun NI3, 4, Mei-jing LI1, 2, Rui XU1, 2, Xing-jie LIANG3, 4, *, Mu-xin GONG1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(1) : 94 - 104
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Acta Pharmaceutica Sinica | 2024, 59(1): 94-104
• Reviews •
Challenges in the study of self-assembled aggregates in decoction of traditional Chinese medicine: A preliminary review
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Qi WANG1, 2, Xiao-meng GUO1, 2, Qian-kun NI3, 4, Mei-jing LI1, 2, Rui XU1, 2, Xing-jie LIANG3, 4, *, Mu-xin GONG1, 2, *
Affiliations
  • 1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • 2. Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Beijing 100069, China
  • 3. Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
  • 4. University of Chinese Academy of Sciences, Beijing 100086, China
Published: 2024-01-12 doi: 10.16438/j.0513-4870.2023-0356
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Decoction is the most commonly used dosage form in the clinical treatment of traditional Chinese medicine (TCM). During boiling, the violent movement of various active ingredients in TCM creates molecular forces such as hydrogen bonding, π-π stacking, hydrophobic interactions and electrostatic interactions, which results in the formation of self-assembled aggregates in decoction (SADs), including particles, gels, fibers, etc. It was found that SADs widely existed in decoction with biological activities superior to both effective monomers and their physical mixtures, providing a new idea to reveal the pharmacodynamic material basis of Chinese herbal medicine from the perspective of component interactions-phase structure. Recently, SADs have become a novel focus of research in TCM. This paper reviewed their relevant studies in recent years and found some issues to be concerned in the research, such as the polydispersity of decoction system, instability of active ingredient interactions during boiling, uncertainty of the aggregates self-assembly rules, and stability, purity, yield of the products. In this regard, some solutions and new ideas were presented for the integrated development and clinical application of SADs.

self-assembly  /  decoction  /  phase state  /  aggregation  /  pharmacodynamic substance
Qi WANG, Xiao-meng GUO, Qian-kun NI, Mei-jing LI, Rui XU, Xing-jie LIANG, Mu-xin GONG. Challenges in the study of self-assembled aggregates in decoction of traditional Chinese medicine: A preliminary review[J]. Acta Pharmaceutica Sinica, 2024 , 59 (1) : 94 -104 . DOI: 10.16438/j.0513-4870.2023-0356
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Article Info
doi: 10.16438/j.0513-4870.2023-0356
  • Receive Date：2023-03-25
  • Online Date：2025-11-28
  • Published：2024-01-12
Article Data
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History
  • Received：2023-03-25
  • Revised：2023-06-01
Funding
Affiliations
    1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
    2. Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Beijing 100069, China
    3. Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
    4. University of Chinese Academy of Sciences, Beijing 100086, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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