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Research progress on the role of cytochrome P450 in plant sesquiterpene biosynthesis
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Shi-xi GAO1, Mei RONG1, Jun-xiang PENG1, Yan-hong XU1, *, Jian-he WEI1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(2) : 313 - 321
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Acta Pharmaceutica Sinica | 2024, 59(2): 313-321
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Research progress on the role of cytochrome P450 in plant sesquiterpene biosynthesis
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Shi-xi GAO1, Mei RONG1, Jun-xiang PENG1, Yan-hong XU1, *, Jian-he WEI1, 2, *
Affiliations
  • 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
  • 2. Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine & Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China
Published: 2024-02-12 doi: 10.16438/j.0513-4870.2023-0677
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Sesquiterpenes are natural terpenoids with 15 carbon atoms in the basic skeleton, which mainly exist in plant volatile oil and have important physiological and medicinal value. Cytochrome P450 (CYP450) is a kind of monooxygenase encoded by supergene family, which is one of the largest gene families in plants. It is involved in the synthesis and metabolism of terpenoids, alkaloids and other secondary metabolites. In the process of terpene biosynthesis, CYP450 participates in the post-modification stage of terpenes by introducing functional groups such as hydroxyl, carboxyl and carbonyl, which plays an important role in enriching the diversity of terpenes. The CYP450 enzymes involved in sesquiterpene synthesis and their substrate catalytic specificity mechanisms have been partially investigated. In this paper, the biosynthetic pathway of plant sesquiterpenes, the structure and classification of CYP450 enzymes were briefly introduced, and the CYP450 enzymes involved in sesquiterpene biosynthesis were summarized, in order to provide a reference for intensive study of the role of CYP450 enzymes in the synthesis of sesquiterpenoids.

sesquiterpenes  /  cytochrome P450  /  biosynthesis regulation  /  secondary metabolite  /  medicinal plant
Shi-xi GAO, Mei RONG, Jun-xiang PENG, Yan-hong XU, Jian-he WEI. Research progress on the role of cytochrome P450 in plant sesquiterpene biosynthesis[J]. Acta Pharmaceutica Sinica, 2024 , 59 (2) : 313 -321 . DOI: 10.16438/j.0513-4870.2023-0677
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doi: 10.16438/j.0513-4870.2023-0677
  • Receive Date：2023-05-30
  • Online Date：2025-11-28
  • Published：2024-02-12
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History
  • Received：2023-05-30
  • Revised：2023-09-11
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Affiliations
    1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
    2. Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine & Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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