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Three 2,3-diketoquinoxaline alkaloids with hepatoprotective activity from Heterosmilax yunnanensis
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Rong-rong DU1, Xin-yi GUO1, Wen-jie QIN2, Hua SUN1, Xiu-mei DUAN2, Xiang YUAN1, Ya-nan YANG1, Kun LI3, *, Pei-cheng ZHANG1, *
Acta Pharmaceutica Sinica | 2024, 59(2) : 413 - 417
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Acta Pharmaceutica Sinica | 2024, 59(2): 413-417
• Original Articles •
Three 2,3-diketoquinoxaline alkaloids with hepatoprotective activity from Heterosmilax yunnanensis
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Rong-rong DU1, Xin-yi GUO1, Wen-jie QIN2, Hua SUN1, Xiu-mei DUAN2, Xiang YUAN1, Ya-nan YANG1, Kun LI3, *, Pei-cheng ZHANG1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Beijing Zhendong Guangming Pharmaceutical Research Institute, Beijing 100085, China
  • 3. Shanxi Zhendong Pharmaceutical Co. Ltd., Changzhi 047100, China
Published: 2024-02-12 doi: 10.16438/j.0513-4870.2023-1218
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Three 2,3-diketoquinoxaline alkaloids were isolated from Heterosmilax yunnanensis Gagnep. Their structures were determined through 1D and 2D NMR, HR-ESI-MS, UV, and IR as 1-[5′-(3″-hydroxy-3″-methyl) glutaryl] ribityl-2,3-diketo-1,2,3,4-tetrahydro-6,7-dimethylquinoxaline (1), 1-[2′-(3″-hydroxy-3″-methyl) glutaryl]ribityl-2,3-diketo-1,2,3,4-tetrahydro-6,7-dimethylquinoxaline (2), and 1-ribityl-2,3-diketo-1,2,3,4-tetrahydro-6,7-dimethylquinoxaline (3). Compounds 1 and 2 are novel compounds, and 3 was isolated from H. yunnanensis for the first time. The hepatoprotective activity of these three compounds was evaluated, with compound 3 showing promising hepatoprotective activity.

Heterosmilax yunnanensis  /  Liliaceae  /  2,3-diketoquinoxaline  /  hepatoprotective activity
Rong-rong DU, Xin-yi GUO, Wen-jie QIN, Hua SUN, Xiu-mei DUAN, Xiang YUAN, Ya-nan YANG, Kun LI, Pei-cheng ZHANG. Three 2,3-diketoquinoxaline alkaloids with hepatoprotective activity from Heterosmilax yunnanensis[J]. Acta Pharmaceutica Sinica, 2024 , 59 (2) : 413 -417 . DOI: 10.16438/j.0513-4870.2023-1218
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doi: 10.16438/j.0513-4870.2023-1218
  • Receive Date：2023-10-30
  • Online Date：2025-11-28
  • Published：2024-02-12
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History
  • Received：2023-10-30
  • Revised：2023-11-28
Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Beijing Zhendong Guangming Pharmaceutical Research Institute, Beijing 100085, China
    3. Shanxi Zhendong Pharmaceutical Co. Ltd., Changzhi 047100, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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