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Research progress of natural product evodiamine-based antitumor drug design strategies
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Zhe-wei XIA, Yu-hang SUN, Tian-le HUANG, Hua SUN, Yu-ping CHEN, Chun-quan SHENG*, Shan-chao WU*
Acta Pharmaceutica Sinica | 2024, 59(3) : 532 - 542
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Acta Pharmaceutica Sinica | 2024, 59(3): 532-542
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Research progress of natural product evodiamine-based antitumor drug design strategies
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Zhe-wei XIA, Yu-hang SUN, Tian-le HUANG, Hua SUN, Yu-ping CHEN, Chun-quan SHENG*, Shan-chao WU*
Affiliations
  • The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China
Published: 2024-03-12 doi: 10.16438/j.0513-4870.2023-0764
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Natural products are important sources for the discovery of anti-tumor drugs. Evodiamine is the main alkaloid component of the traditional Chinese herb Wu-Chu-Yu, and it has weak antitumor activity. In recent years, a number of highly active antitumor candidates have been discovered with a significant progress. This article reviews the research progress of evodiamine-based antitumor drug design strategies, in order to provide reference for the development of new drugs with natural products as leads.

natural product  /  evodiamine  /  drug design  /  structural optimization  /  antitumor
Zhe-wei XIA, Yu-hang SUN, Tian-le HUANG, Hua SUN, Yu-ping CHEN, Chun-quan SHENG, Shan-chao WU. Research progress of natural product evodiamine-based antitumor drug design strategies[J]. Acta Pharmaceutica Sinica, 2024 , 59 (3) : 532 -542 . DOI: 10.16438/j.0513-4870.2023-0764
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Year 2024 volume 59 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2023-0764
  • Receive Date：2023-06-20
  • Online Date：2025-11-28
  • Published：2024-03-12
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  • Received：2023-06-20
  • Revised：2023-08-28
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    The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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