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Preparation modification strategies for clinical treatment drugs of Parkinson's disease
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Meng-jiao HE1, Yi-fang XIAO1, Xiang-an-ni KONG1, Zhi-hao LIU1, Xiao-guang WANG2, Hao FENG2, Jia-sheng TU1, Qian CHEN1, *, Chun-meng SUN1, *
Acta Pharmaceutica Sinica | 2024, 59(3) : 574 - 580
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Acta Pharmaceutica Sinica | 2024, 59(3): 574-580
• Reviews •
Preparation modification strategies for clinical treatment drugs of Parkinson's disease
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Meng-jiao HE1, Yi-fang XIAO1, Xiang-an-ni KONG1, Zhi-hao LIU1, Xiao-guang WANG2, Hao FENG2, Jia-sheng TU1, Qian CHEN1, *, Chun-meng SUN1, *
Affiliations
  • 1. NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
  • 2. Nanjing Lanming Biomedical Technology Co., Ltd., Nanjing 210028, China
Published: 2024-03-12 doi: 10.16438/j.0513-4870.2023-0972
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Parkinson's disease (PD) is a chronic neurodegenerative disease. At present, levodopa and other drugs are mainly used for dopamine supplementation therapy. However, the absorption of levodopa in the gastrointestinal tract is unstable and its half-life is short, and long-term use of levodopa will lead to the end-of-dose deterioration, dyskinesia, the "ON-OFF" phenomenon and other symptoms. Therefore, new preparations need to be developed to improve drug efficacy, reduce side effects or improve compliance of patients. Based on the above clinical needs, this review briefly introduced the preparation modification strategies for the treatment of PD through case analysis, in order to provide references for the research and development of related preparations.

Parkinson's disease  /  levodopa  /  carbidopa  /  dopamine agonist  /  dosage form
Meng-jiao HE, Yi-fang XIAO, Xiang-an-ni KONG, Zhi-hao LIU, Xiao-guang WANG, Hao FENG, Jia-sheng TU, Qian CHEN, Chun-meng SUN. Preparation modification strategies for clinical treatment drugs of Parkinson's disease[J]. Acta Pharmaceutica Sinica, 2024 , 59 (3) : 574 -580 . DOI: 10.16438/j.0513-4870.2023-0972
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Article Info
doi: 10.16438/j.0513-4870.2023-0972
  • Receive Date：2023-08-15
  • Online Date：2025-11-28
  • Published：2024-03-12
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History
  • Received：2023-08-15
  • Revised：2024-01-09
Affiliations
    1. NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
    2. Nanjing Lanming Biomedical Technology Co., Ltd., Nanjing 210028, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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