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Biosensor analysis technology and its research progress in drug development of Alzheimer's disease
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Shu-qi SHEN1, Jia-hao FANG1, Hui WANG1, Liang CHAO1, Piao-xue YOU2, Zhan-ying HONG1, *
Acta Pharmaceutica Sinica | 2024, 59(3) : 554 - 564
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Acta Pharmaceutica Sinica | 2024, 59(3): 554-564
• Reviews •
Biosensor analysis technology and its research progress in drug development of Alzheimer's disease
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Shu-qi SHEN1, Jia-hao FANG1, Hui WANG1, Liang CHAO1, Piao-xue YOU2, Zhan-ying HONG1, *
Affiliations
  • 1. School of Pharmacy, Naval Medical University, Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai 200433, China
  • 2. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
Published: 2024-03-12 doi: 10.16438/j.0513-4870.2023-0818
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Biosensor analysis technology is a kind of technology with high specificity that can convert biological reactions into optical and electrical signals. In the development of drugs for Alzheimer's disease (AD), according to different disease hypotheses and targets, this technology plays an important role in confirming targets and screening active compounds. This paper briefly describes the pathogenesis of AD and the current situation of therapeutic drugs, introduces three biosensor analysis techniques commonly used in the discovery of AD drugs, such as surface plasmon resonance (SPR), biolayer interferometry (BLI) and fluorescence analysis technology, explains its basic principle and application progress, and summarizes their advantages and limitations respectively.

Alzheimer's disease  /  biosensor  /  surface plasmon resonance  /  biolayer interferometry  /  fluorescence analysis technology  /  drug screening
Shu-qi SHEN, Jia-hao FANG, Hui WANG, Liang CHAO, Piao-xue YOU, Zhan-ying HONG. Biosensor analysis technology and its research progress in drug development of Alzheimer's disease[J]. Acta Pharmaceutica Sinica, 2024 , 59 (3) : 554 -564 . DOI: 10.16438/j.0513-4870.2023-0818
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Year 2024 volume 59 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2023-0818
  • Receive Date：2023-07-03
  • Online Date：2025-11-28
  • Published：2024-03-12
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History
  • Received：2023-07-03
  • Revised：2023-08-25
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Affiliations
    1. School of Pharmacy, Naval Medical University, Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai 200433, China
    2. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
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