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Study on the chemical constituents of triterpenoids in Patrinia villosa Juss.
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Qi-guo WU1, 3, Le-yi HUANG3, 4, Zhi CHEN1, Dong-feng LIU5, Yong-li WANG3, Gui-xin CHOU2, 3, *
Acta Pharmaceutica Sinica | 2024, 59(4) : 1005 - 1009
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Acta Pharmaceutica Sinica | 2024, 59(4): 1005-1009
• Original Articles •
Study on the chemical constituents of triterpenoids in Patrinia villosa Juss.
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Qi-guo WU1, 3, Le-yi HUANG3, 4, Zhi CHEN1, Dong-feng LIU5, Yong-li WANG3, Gui-xin CHOU2, 3, *
Affiliations
  • 1. Department of Pharmacy, Anqing Medical College, Anqing 246052, China
  • 2. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 3. Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201203, China
  • 4. State Key Lab. of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China
  • 5. Anqing food and drug inspection Center, Anqing 246000, China
Published: 2024-04-12 doi: 10.16438/j.0513-4870.2023-1170
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Seven triterpenoids were isolated and purified from the 95% aqueous EtOH extract whole plants of P. villosa by various chromatographic techniques, such as silica gel, ODS, Sephadex LH-20 gel column chromatography and preparative high performance liquid chromatography. Based on physicochemical properties and spectral analyses, the structures of the seven compounds were identified as 29-acetoxyoleanolic acid-3-O-α-L-arabinopyranoside (1), oleanolic acid (2), 3β-hydroxy-24-norursa-4(23), 12, 20(30)-trien-28-oic acid (3), 3β-hydroxy-24-nor-urs-4(23), 12-dien-28-oic acid (4), ursolic acid (5), hederagenin (6), oleanolic acid 3-O-arabinoside (7). Compound 1 is a new compound. Compounds 3, 4, 6, and 7 are isolated from P. villosa for the first time. All compounds were assayed for their anti-inflammatory activity by the prodution of NO in lipopolysaccharide-stimulated RAW 264.7 cells. The results showed that compounds 1, 2, 3, 4, 6, and 7 significantly inhibited the NO release.

Patrinia villosa Juss.  /  triterpenoid  /  anti-inflammatory  /  chemical constituent
Qi-guo WU, Le-yi HUANG, Zhi CHEN, Dong-feng LIU, Yong-li WANG, Gui-xin CHOU. Study on the chemical constituents of triterpenoids in Patrinia villosa Juss.[J]. Acta Pharmaceutica Sinica, 2024 , 59 (4) : 1005 -1009 . DOI: 10.16438/j.0513-4870.2023-1170
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Article Info
doi: 10.16438/j.0513-4870.2023-1170
  • Receive Date：2023-10-16
  • Online Date：2025-11-28
  • Published：2024-04-12
Article Data
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History
  • Received：2023-10-16
  • Revised：2023-11-16
Funding
Affiliations
    1. Department of Pharmacy, Anqing Medical College, Anqing 246052, China
    2. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    3. Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai 201203, China
    4. State Key Lab. of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China
    5. Anqing food and drug inspection Center, Anqing 246000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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