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Research progress on detection methods and traceability of alkaloid toxins in Aconitum species
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Tian-yu LIU1, Ge SONG2, Rui-qin YANG1, *, Yun-feng ZHANG2, *, Cheng-long ZHANG1
Acta Pharmaceutica Sinica | 2024, 59(4) : 899 - 907
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Acta Pharmaceutica Sinica | 2024, 59(4): 899-907
• Reviews •
Research progress on detection methods and traceability of alkaloid toxins in Aconitum species
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Tian-yu LIU1, Ge SONG2, Rui-qin YANG1, *, Yun-feng ZHANG2, *, Cheng-long ZHANG1
Affiliations
  • 1. School of Investigation, People's Public Security University of China, Beijing 100038, China
  • 2. Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China
Published: 2024-04-12 doi: 10.16438/j.0513-4870.2023-0984
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As the predominant toxic constituent within the Aconitum genus, Aconitum alkaloids (ATs) exhibit both significant pharmaceutical value and substantial toxicity, have been widely used in traditional Chinese medicine and the realm of contemporary clinical medicine. However, owing to their high toxicity, inappropriate employment of ATs in pharmaceuticals, edibles, and the environment will pose serious threats to human health, inciting a series of toxic incidents. Consequently, it is very important to develop effective analytical methods. This paper presents a comprehensive review of the advancements in research pertaining to the pretreatment and detection methods in common substrates, including high performance liquid chromatography, liquid chromatography-mass spectrometry and rapid detection methods. To explore the specific sources of ATs in actual poisoning cases, the comprehensive traceability strategy based on plant morphology, chemical fingerprint analysis and DNA barcoding technology was discussed, proposing a comprehensive prospect for the development of ATs analysis and traceability, in order to provide guidance for related research within the forensic science domain.

Aconitum  /  alkaloid  /  detection  /  fingerprint analysis  /  traceability
Tian-yu LIU, Ge SONG, Rui-qin YANG, Yun-feng ZHANG, Cheng-long ZHANG. Research progress on detection methods and traceability of alkaloid toxins in Aconitum species[J]. Acta Pharmaceutica Sinica, 2024 , 59 (4) : 899 -907 . DOI: 10.16438/j.0513-4870.2023-0984
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Article Info
doi: 10.16438/j.0513-4870.2023-0984
  • Receive Date：2023-08-21
  • Online Date：2025-11-28
  • Published：2024-04-12
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  • Received：2023-08-21
  • Revised：2023-10-17
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Affiliations
    1. School of Investigation, People's Public Security University of China, Beijing 100038, China
    2. Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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