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The activity and mechanism of action of a novel Candida albicans biofilm inhibitor IMB-H12
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Dan LI1, Xiao-hong ZHU2, Cong BIAN2, Yuan-juan WEI2, Wen-jing SHI2, Yan LI2, *, Li-jie YUAN1, *
Acta Pharmaceutica Sinica | 2024, 59(4) : 948 - 956
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Acta Pharmaceutica Sinica | 2024, 59(4): 948-956
• Original Articles •
The activity and mechanism of action of a novel Candida albicans biofilm inhibitor IMB-H12
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Dan LI1, Xiao-hong ZHU2, Cong BIAN2, Yuan-juan WEI2, Wen-jing SHI2, Yan LI2, *, Li-jie YUAN1, *
Affiliations
  • 1. Hebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China
  • 2. Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2024-04-12 doi: 10.16438/j.0513-4870.2023-1220
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Candida albicans (C. albicans) stands as the primary opportunistic fungal pathogen responsible for fungal infections. The formation of biofilms constitutes a key virulence trait of C. albicans and a pivotal factor in drug resistance. Consequently, the development of antifungal drugs possessing biofilm inhibitory properties holds importance in the treatment of fungal infectious diseases. This study conducted in-depth research of the novel biofilm inhibitor named 1-(cyclopentylamino)-3-(4-(2, 4, 4-trimethylpentan-2-yl)phenoxy)propan-2-ol (IMB-H12). IMB-H12 showed good inhibitory activity on the formation of biofilms and a certain scavenging effect on mature biofilms. Preliminary research on the mechanism of action has found that IMB-H12 can inhibit the transformation from yeast to hyphal phase, inhibit the formation of mycelium, and reduce the adhesion activity and hydrophobicity of Candida albicans. IMB-H12 could also induce changes in the content of cell wall components, downregulate the expression of multiple genes related to adhesion and hyphal formation. Therefore, further research on this compound is expected to discover new lead compounds with antifungal activity.

Candida albicans  /  biofilm  /  1-(cyclopentylamino)-3-(4-(2, 4, 4-trimethylpentan-2-yl)phenoxy)propan-2-ol  /  adhere  /  hyphae
Dan LI, Xiao-hong ZHU, Cong BIAN, Yuan-juan WEI, Wen-jing SHI, Yan LI, Li-jie YUAN. The activity and mechanism of action of a novel Candida albicans biofilm inhibitor IMB-H12[J]. Acta Pharmaceutica Sinica, 2024 , 59 (4) : 948 -956 . DOI: 10.16438/j.0513-4870.2023-1220
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Year 2024 volume 59 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2023-1220
  • Receive Date：2023-10-30
  • Online Date：2025-11-28
  • Published：2024-04-12
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History
  • Received：2023-10-30
  • Revised：2023-11-27
Funding
Affiliations
    1. Hebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China
    2. Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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