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Research progress on the endocytosis pathway of nanoscale metal-organic frameworks drug carriers
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Yu-xuan WANG1, Wen-jia XIE1, Hui-le GAO2, Xi-bo PEI1, *
Acta Pharmaceutica Sinica | 2024, 59(5) : 1196 - 1209
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Acta Pharmaceutica Sinica | 2024, 59(5): 1196-1209
• Reviews •
Research progress on the endocytosis pathway of nanoscale metal-organic frameworks drug carriers
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Yu-xuan WANG1, Wen-jia XIE1, Hui-le GAO2, Xi-bo PEI1, *
Affiliations
  • 1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • 2. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
Published: 2024-05-12 doi: 10.16438/j.0513-4870.2024-0226
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Metal-organic frameworks (MOFs) are crystalline materials with a multidimensional porous network structure, formed through coordination bonds with metal ions as nodes and organic ligands as connecting bridges. Due to their excellent physicochemical properties, MOFs have extensive applications in the field of biomedicine, ranging from antibacterials, drug carriers, imaging to sensors. Nanoscale metal-organic frameworks (nMOFs), commonly utilized drug carriers, can gain enhanced safety, targeted delivery, and superior therapeutic effect through endocytosis. In this review, we comprehensively summarize the factors influencing the endocytosis of nMOFs, focusing on three key physicochemical properties, particle size, morphology and surface modification. Based on different illness models, the review succinctly summarizes the latest advancements in understanding the endocytosis pathways of nMOFs while critically reflecting on the inherent limitations of current research methods. Lastly, the review offers valuable insights into future research methodologies and objectives, aiming to lay the groundwork and provide meaningful guidance for the synthesis and development of nMOFs as promising versatile drug carriers.

metal-organic framework  /  drug carrier  /  endocytosis  /  nanomaterial  /  drug therapy
Yu-xuan WANG, Wen-jia XIE, Hui-le GAO, Xi-bo PEI. Research progress on the endocytosis pathway of nanoscale metal-organic frameworks drug carriers[J]. Acta Pharmaceutica Sinica, 2024 , 59 (5) : 1196 -1209 . DOI: 10.16438/j.0513-4870.2024-0226
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Article Info
doi: 10.16438/j.0513-4870.2024-0226
  • Receive Date：2024-03-12
  • Online Date：2025-11-27
  • Published：2024-05-12
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  • Received：2024-03-12
  • Revised：2024-04-06
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Affiliations
    1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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