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A new hexacyclic triterpenoid with 13α,27-cyclopropane ring from Glechoma longituba
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Qian ZHANG1, 2, Mei-long LU1, 2, Tian-zi LIU1, 2, Yue-ting ZHANG1, 2, Ao ZHU1, 2, Li-li DING1, 2, Zhu-zhen HAN1, 2, *, Li-hua GU1, 2, *, Zheng-tao WANG1, 2
Acta Pharmaceutica Sinica | 2024, 59(5) : 1334 - 1340
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Acta Pharmaceutica Sinica | 2024, 59(5): 1334-1340
• Original Articles •
A new hexacyclic triterpenoid with 13α,27-cyclopropane ring from Glechoma longituba
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Qian ZHANG1, 2, Mei-long LU1, 2, Tian-zi LIU1, 2, Yue-ting ZHANG1, 2, Ao ZHU1, 2, Li-li DING1, 2, Zhu-zhen HAN1, 2, *, Li-hua GU1, 2, *, Zheng-tao WANG1, 2
Affiliations
  • 1. The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China
Published: 2024-05-12 doi: 10.16438/j.0513-4870.2023-1225
Outline
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In order to study the compounds from Glechoma longituba (Nakai) Kupr. and explore the substance bases of its dissipating blood stasis, MCI, silica gel, Sephadex LH-20, ODS column chromatography and preparative thin layer chromatography were used to isolate and purify the compounds. The structures were identified by MS, 1D NMR, and 2D NMR spectra analysis, etc. Eight triterpenoids were isolated from dichloromethane fraction of ethanol extract from G. longituba and identified as 2α,3α,16β-trihydroxy-13α,27-cyclours-11-en-28-oic acid (1), 28-norurs-12-ene-3β,17β-diol (2), 28-norolean-12-ene-3β,17β-diol (3), oleanonic acid (4), 3β,13β-dihydroxyurs-11-en-28-oic acid (5), uvaol (6), oleanolic acid (7), ursolic acid (8). Compound 1 is a new hexacyclic triterpene with 13α,27-cyclopropane structure, named euscaphic acid H; compounds 2 and 3 were isolated from Lamiaceae for the first time while compounds 4 and 5 were isolated from this genus. The in vitro anticoagulant activity of triterpenoids was evaluated by four coagulation indexes (activated partial thromboplastin time, APTT; thrombin time, TT; prothrombin time, PT; fibrinogen, FIB). Among them, compounds 1 and 6 showed obvious anticoagulant effects.

Glechomae Herba  /  Glechoma longituba (Nakai) Kupr.  /  hexacyclic triterpene  /  chemical composition  /  anticoagulation
Qian ZHANG, Mei-long LU, Tian-zi LIU, Yue-ting ZHANG, Ao ZHU, Li-li DING, Zhu-zhen HAN, Li-hua GU, Zheng-tao WANG. A new hexacyclic triterpenoid with 13α,27-cyclopropane ring from Glechoma longituba[J]. Acta Pharmaceutica Sinica, 2024 , 59 (5) : 1334 -1340 . DOI: 10.16438/j.0513-4870.2023-1225
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Article Info
doi: 10.16438/j.0513-4870.2023-1225
  • Receive Date：2023-10-31
  • Online Date：2025-11-27
  • Published：2024-05-12
Article Data
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History
  • Received：2023-10-31
  • Revised：2023-12-28
Funding
Affiliations
    1. The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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