Home Journals Articles Updates About
CN
image
收藏切换
The mechanism of anticoronaviral action of CDK inhibitor flavopiridol
收藏切换
PDF
Li-dan WANG, Sai-sai GUO, Shan CEN*
Acta Pharmaceutica Sinica | 2024, 59(5) : 1280 - 1285
Less
收藏切换
Acta Pharmaceutica Sinica | 2024, 59(5): 1280-1285
• Original Articles •
The mechanism of anticoronaviral action of CDK inhibitor flavopiridol
Full
Li-dan WANG, Sai-sai GUO, Shan CEN*
Affiliations
  • Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2024-05-12 doi: 10.16438/j.0513-4870.2024-0039
Outline
收藏切换

Coronaviruses of the genus Coronavirus contain a variety of human pathogenic viruses, and the development of anti-coronavirus drugs is of great value. The development of antiviral drugs targeting host cells is not only helpful for the development of new antiviral strategies, but also for solving problems such as drug resistance due to viral mutations. Our preliminary study identified that cell cycle-dependent protein kinases (CDKs) involved in coronavirus replication, for which they would be potential anticoronaviral targets. In this study, we found that the broad-spectrum CDK inhibitor flavopiridol significantly inhibited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA dependent RNA polymerase (RdRp) activity. Further studies showed that flavopiridol suppressed the RNA synthesis efficiency of SARS-CoV-2 RdRp. In addition, flavopiridol effectively restricted the replication of human coronavirus OC43 (HCoV-OC43). Therefore, our study suggested that the CDK inhibitor flavopiridol may be a potential anticoronaviral drug.

flavopiridol  /  CDK inhibitor  /  coronavirus  /  antiviral  /  RNA dependent RNA polymerase
Li-dan WANG, Sai-sai GUO, Shan CEN. The mechanism of anticoronaviral action of CDK inhibitor flavopiridol[J]. Acta Pharmaceutica Sinica, 2024 , 59 (5) : 1280 -1285 . DOI: 10.16438/j.0513-4870.2024-0039
Appendix
Less
Year 2024 volume 59 Issue 5
PDF
199
90
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2024-0039
  • Receive Date：2024-01-12
  • Online Date：2025-11-27
  • Published：2024-05-12
Article Data
Affiliations
History
  • Received：2024-01-12
  • Revised：2024-02-22
Funding
Affiliations
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2024-0039
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House