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Research progress on small-molecule inhibitors targeting TNIK in cancer treatment
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Meng-xiao CHEN1, Yi HE1, *, Shen-you NIE1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(5) : 1151 - 1162
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Acta Pharmaceutica Sinica | 2024, 59(5): 1151-1162
• Reviews •
Research progress on small-molecule inhibitors targeting TNIK in cancer treatment
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Meng-xiao CHEN1, Yi HE1, *, Shen-you NIE1, 2, *
Affiliations
  • 1. Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China
  • 2. Department of Urology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
Published: 2024-05-12 doi: 10.16438/j.0513-4870.2023-1095
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Traf2- and Nck-interacting kinase (TNIK) is closely related to the cancer occurrence, development, and prognosis. TNIK plays an important role in regulating Wnt/β-catenin pathway, thus becoming a potential target for cancer treatment. Various small-molecule TNIK inhibitors with diverse structures and potent in vitro activities have been developed to treat tumors. However, no TNIK inhibitor has entered clinical phase mainly due to poor selectivity, toxicity, and unsatisfied in vivo anti-tumor efficiency. This review summarizes the research progress of small molecule inhibitors targeting TNIK, with the aim of giving some guidance for future research and development of small-molecule inhibitors.

Traf2- and Nck-interacting kinase  /  wnt/β-catenin  /  small molecule inhibitor  /  kinase  /  anti-tumor
Meng-xiao CHEN, Yi HE, Shen-you NIE. Research progress on small-molecule inhibitors targeting TNIK in cancer treatment[J]. Acta Pharmaceutica Sinica, 2024 , 59 (5) : 1151 -1162 . DOI: 10.16438/j.0513-4870.2023-1095
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Year 2024 volume 59 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2023-1095
  • Receive Date：2023-09-22
  • Online Date：2025-11-27
  • Published：2024-05-12
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History
  • Received：2023-09-22
  • Revised：2024-02-19
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Affiliations
    1. Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, Ministry of Education, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China
    2. Department of Urology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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