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Research advances of living microorganisms and their derivatives-based strategies for the treatment of bacterial infection
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Xue-yu PU1, 2, Xi WANG1, 2, Gui-quan LIU1, 2, Jian YANG1, 2, 3, *
Acta Pharmaceutica Sinica | 2024, 59(5) : 1186 - 1195
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Acta Pharmaceutica Sinica | 2024, 59(5): 1186-1195
• Reviews •
Research advances of living microorganisms and their derivatives-based strategies for the treatment of bacterial infection
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Xue-yu PU1, 2, Xi WANG1, 2, Gui-quan LIU1, 2, Jian YANG1, 2, 3, *
Affiliations
  • 1. State Key Laboratory of Component-Based Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 2. Institute of Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 3. Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
Published: 2024-05-12 doi: 10.16438/j.0513-4870.2023-1060
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In recent years, the abuse of antibiotics has led to antibiotic tolerance in the process of bacterial treatment, the morbidity and mortality caused by drug-resistant bacterial infection have further increased significantly. Drug delivery systems can be precisely designed to achieve controlled drug release, thereby reducing the risk of antibiotic toxicity and resistance, it is urgent to seek novel drug delivery systems to address the challenges posed by bacterial infections. This review first outlines the epidemic and prevention situation of bacterial infection, and further summarizes living microorganisms and their derivatives-based drug delivery systems, focusing on their natural characteristics such as surface specific proteins, physiological signal sensing, directed movement, and secretion of antibacterial substances, which show great potential in the treatment of bacterial infectious diseases by demonstrating their antibacterial effects. This review aims to provide ideas for the development of novel drug delivery systems based on living microorganisms and their derivatives for the treatment of bacterial infectious diseases.

anti-bacterial infection strategy  /  living microorganism  /  bacterial derivative  /  drug delivery system  /  bacterial infection
Xue-yu PU, Xi WANG, Gui-quan LIU, Jian YANG. Research advances of living microorganisms and their derivatives-based strategies for the treatment of bacterial infection[J]. Acta Pharmaceutica Sinica, 2024 , 59 (5) : 1186 -1195 . DOI: 10.16438/j.0513-4870.2023-1060
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Year 2024 volume 59 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2023-1060
  • Receive Date：2023-09-13
  • Online Date：2025-11-27
  • Published：2024-05-12
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History
  • Received：2023-09-13
  • Revised：2024-01-22
Funding
Affiliations
    1. State Key Laboratory of Component-Based Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2. Institute of Chinese Medicine of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    3. Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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