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Study on the chemical constituents and antitumor activity of ethyl acetate extract of Lindera reflexa from Hunan province
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Shan-shan ZHANG1, 2, Yue HAN1, 2, Ya-di HOU1, 2, Yu-jie WEI1, Xiao-ya SUN1, 2, *, Sui-qing CHEN1, 2, 3, *
Acta Pharmaceutica Sinica | 2024, 59(6) : 1741 - 1750
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Acta Pharmaceutica Sinica | 2024, 59(6): 1741-1750
• Original Articles •
Study on the chemical constituents and antitumor activity of ethyl acetate extract of Lindera reflexa from Hunan province
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Shan-shan ZHANG1, 2, Yue HAN1, 2, Ya-di HOU1, 2, Yu-jie WEI1, Xiao-ya SUN1, 2, *, Sui-qing CHEN1, 2, 3, *
Affiliations
  • 1. Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Henan Key Laboratory of Chinese Medicine Resources and Chinese Medicine Chemistry, Zhengzhou 450046, China
  • 3. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China, Zhengzhou 450046, China
Published: 2024-06-12 doi: 10.16438/j.0513-4870.2023-1279
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The compounds were isolated and purified by silica gel, MCI, Sephadex LH-20 and semi-preparative high performance liquid chromatography. The structures of the compounds were determined by NMR and MS spectroscopic data. Twenty monomer compounds were isolated from the ethyl acetate extract of Lindera reflexa root from Hunan province, and identified as: (1″S, 3″S, 6″R)-2′, 4′, 6′-trihydroxy-3′-[1″-(3″-hydroxy)-p-menthanyl]-chalcone (1), sumadain D (2), quercetin (3), catechin (4), epicatechin (5), N-cis-feruloyltyramine (6), N-trans-feruloyltyramine (7), N-trans-feruloyl-3-methoxytyramine (8), flavifloramides B (9), northalifoline (10), isolariciresinol (11), syringaresinol (12), pinoresinol (13), medioresinol (14), dehydroconiferyl alcohol (15), 4-methoxyl-denudaquinol (16), miliusanal (17), syringic acid (18), abscisic acid (19), (E)-cinnamyl-(E)-cinnamate (20). Compound 1 is a new compound, and compounds 2‒20 have been isolated from Lindera reflexa for the first time. The results showed that compounds 1, 2, 3 and 16 could significantly reduce the survival ability of MGC-803 cells with IC50 values of 5.58, 23.41, 25.72 and 20.96 μmol·L-1, respectively. Compounds 5 and 20 can reduce the survival ability of MGC-803 cells with IC50 values of 98.83 and 89.26 μmol·L-1, respectively.

Lindera reflexa  /  antitumor activity  /  flavonoid  /  amide  /  lignane
Shan-shan ZHANG, Yue HAN, Ya-di HOU, Yu-jie WEI, Xiao-ya SUN, Sui-qing CHEN. Study on the chemical constituents and antitumor activity of ethyl acetate extract of Lindera reflexa from Hunan province[J]. Acta Pharmaceutica Sinica, 2024 , 59 (6) : 1741 -1750 . DOI: 10.16438/j.0513-4870.2023-1279
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doi: 10.16438/j.0513-4870.2023-1279
  • Receive Date：2023-11-10
  • Online Date：2025-11-26
  • Published：2024-06-12
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History
  • Received：2023-11-10
  • Revised：2024-02-19
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Affiliations
    1. Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Henan Key Laboratory of Chinese Medicine Resources and Chinese Medicine Chemistry, Zhengzhou 450046, China
    3. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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