收藏切换
Advances in the study of methyltransferase in drug metabolism
收藏切换
PDF
Jie-yi CHEN, Li SHENG*
Acta Pharmaceutica Sinica | 2024, 59(6) : 1562 - 1568
Less
收藏切换
Acta Pharmaceutica Sinica | 2024, 59(6): 1562-1568
Reviews
Advances in the study of methyltransferase in drug metabolism
Full
Jie-yi CHEN, Li SHENG*
Affiliations
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Key Laboratory of Nonclinical Drug Metabolism and PK/PD Research of Innovative Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Published: 2024-06-12 doi: 10.16438/j.0513-4870.2024-0014
Outline
收藏切换

Methyltransferase is an important metabolic enzyme whose main function is to catalyze the methylation of nitrogen, oxygen and sulfur atoms. It plays an important role in the metabolism of exogenous and exogenous compounds, including drugs in vivo. Methyltransferases are widely distributed in different tissues, with the liver and kidneys being the most abundant. In addition, the structure and activity of the enzyme have certain species and individual differences. This article will describe the biological properties of methyltransferases and their role in drug metabolism.

methyltransferase  /  tissue distribution  /  gene polymorphism  /  drug interaction  /  drug metabolism
Jie-yi CHEN, Li SHENG. Advances in the study of methyltransferase in drug metabolism[J]. Acta Pharmaceutica Sinica, 2024 , 59 (6) : 1562 -1568 . DOI: 10.16438/j.0513-4870.2024-0014
Year 2024 volume 59 Issue 6
PDF
284
131
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2024-0014
  • Receive Date:2024-01-05
  • Online Date:2025-11-26
  • Published:2024-06-12
Article Data
Affiliations
History
  • Received:2024-01-05
  • Revised:2024-01-31
Funding
Affiliations
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Key Laboratory of Nonclinical Drug Metabolism and PK/PD Research of Innovative Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2024-0014
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT