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A new aurone glycoside from the whole plant of Bidens pilosa L.
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Chang LIU1, 2, Yu HAN2, 3, Jiao LIU2, 3, Tao ZHANG2, *, Zhong-mei ZOU1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(6) : 1757 - 1764
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Acta Pharmaceutica Sinica | 2024, 59(6): 1757-1764
• Original Articles •
A new aurone glycoside from the whole plant of Bidens pilosa L.
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Chang LIU1, 2, Yu HAN2, 3, Jiao LIU2, 3, Tao ZHANG2, *, Zhong-mei ZOU1, 2, *
Affiliations
  • 1. Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
  • 3. Shenyang Pharmaceutical University, Shenyang 110016, China
Published: 2024-06-12 doi: 10.16438/j.0513-4870.2023-1327
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Ten compounds were isolated from the 95% ethanol extract of the whole plant of Bidens pilosa L. by silica gel column chromatography, polyamide column chromatography, Sephadex LH-20 column chromatography, MCI column chromatography, and semi-preparative HPLC methods. Based on its physicochemical properties and spectral data (UV, IR, MS, NMR), the structures of the isolates were identified as bidpilaurone glycoside A (1), Z-6-O-(4″-O-acetyl-6″-O-p-coumarinyl-β-D-glucopyranosyl)-6, 7, 3′, 4′-tetrahydroxyaurone (2), okanin 4′-O-β-D-(4″, 6″-diacetyl) glucopyranoside (3), Z-6-O-(6″-O-acetyl-β-D-glucopyranosyl)-6, 7, 3′, 4′-tetrahydroxyaurone (4), 6, 7, 3, 4′-tetrahydroxyaurone (5), Z-6-O-(6-O-coumarinyl-β-D-glucopyranosyl)-6, 7, 3′, 4′-tetrahydroxyaurone (6), Z-6-O-(4, 6-acetyl-β-D-pyranosyl)-6, 7, 3, 4′-tetrahydroxyaurone (7), Z-6-O-(6″-O-p-coumarinyl-β-D-glucopyranosyl)-6, 7, 3′, 4′-tetrahydroxyaurone (8), luteolin (9), and 7-O-β-D-glucopyranosyl-5, 3′-dihydroxy-3, 6, 4′-trimethoxyflavone (10). Among them, compound 1 was a new aurone glycoside from B. pilosa L. Compounds 4 and 9 could partially inhibit the lipid deposition induced by sodium oleate and palmitate in human liver HepG2 cells. Molecular docking technology predicts that the potential target for its hypolipidemic activity may be peroxisome proliferator-activated receptors γ (PPARγ).

Asteraceae  /  Bidens pilosa L.  /  chemical composition  /  aurone  /  hypolipidemic activity
Chang LIU, Yu HAN, Jiao LIU, Tao ZHANG, Zhong-mei ZOU. A new aurone glycoside from the whole plant of Bidens pilosa L.[J]. Acta Pharmaceutica Sinica, 2024 , 59 (6) : 1757 -1764 . DOI: 10.16438/j.0513-4870.2023-1327
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Year 2024 volume 59 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2023-1327
  • Receive Date：2023-11-24
  • Online Date：2025-11-26
  • Published：2024-06-12
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History
  • Received：2023-11-24
  • Revised：2024-03-12
Funding
Affiliations
    1. Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
    3. Shenyang Pharmaceutical University, Shenyang 110016, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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