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Studies on the chemical composition of Ferula feruloides
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Ying-he BI1, Ke-jian PANG2, Hui-zi LI1, Yerlan BAHETJAN1, Muguli MUHAXI2, Yan HU1, *, Xin-zhou YANG1, *
Acta Pharmaceutica Sinica | 2024, 59(7) : 2069 - 2076
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Acta Pharmaceutica Sinica | 2024, 59(7): 2069-2076
• Original Articles •
Studies on the chemical composition of Ferula feruloides
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Ying-he BI1, Ke-jian PANG2, Hui-zi LI1, Yerlan BAHETJAN1, Muguli MUHAXI2, Yan HU1, *, Xin-zhou YANG1, *
Affiliations
  • 1. College of Pharmacy, South-Central Minzu University, Wuhan 430074, China
  • 2. Yili Normal University, Yining 835000, China
Published: 2024-07-12 doi: 10.16438/j.0513-4870.2023-1424
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Eleven compounds were isolated and purified from the ethyl acetate part of 80% ethanol extract of Ferula feruloides root by a combination of normal-phase silica gel column chromatography, Sephadex LH-20 dextran gel column chromatography and semi-preparative liquid chromatography and then modern wave spectrometry methods (NMR, MS, UV, IR) were used to identify the structures of the compounds, which were identified as baigene D (1), baigene E (2), baigene F (3), β-kirialovin (4), α-kirialovin (5), falcarindiol (6), ammoresinol (7), dshamirone (8), 2, 3-dihydro-7-hydroxy-2S*, 3R*-dimethyl-3-[4-methyl-5-(4-methy1-2-furyl)-3(E)-pentenyl]-furo[3, 2-c]coumarin (9), 2, 3-dihydro-7-hydroxy-2S*, 3R*-dimethyl-2-[4, 8-dimethyl-3(E), 7-nonadi-enyl]-furo[3, 2-c]coumarin (10), and baigene C (11). Compounds 1-3 are new coumarin analogues, and compounds 4-6 are firstly isolated from F. feruloides. The anti-proliferative activity of compounds 5, 7-11 against human gastric cancer (MKN-45) cells was evaluated using MTT assay, which showed that compounds 7-11 exhibited strong inhibitory activity, and compound 5 exhibited weak inhibitory activity.

Ferula L.  /  Ferula feruloides  /  chemical composition  /  coumarin  /  sesquiterpene
Ying-he BI, Ke-jian PANG, Hui-zi LI, Yerlan BAHETJAN, Muguli MUHAXI, Yan HU, Xin-zhou YANG. Studies on the chemical composition of Ferula feruloides[J]. Acta Pharmaceutica Sinica, 2024 , 59 (7) : 2069 -2076 . DOI: 10.16438/j.0513-4870.2023-1424
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Article Info
doi: 10.16438/j.0513-4870.2023-1424
  • Receive Date：2023-12-20
  • Online Date：2025-11-26
  • Published：2024-07-12
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History
  • Received：2023-12-20
  • Revised：2024-02-29
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Affiliations
    1. College of Pharmacy, South-Central Minzu University, Wuhan 430074, China
    2. Yili Normal University, Yining 835000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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