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Interactions between gut microbiota-producing enzymes and natural drugs affect disease progression
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Zhi-yu WANG1, Hao-ran SHEN1, Yan-xing HAN1, Jian-dong JIANG1, 3, Wei JIANG2, *, Hui-hui GUO1, *
Acta Pharmaceutica Sinica | 2024, 59(8) : 2183 - 2191
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Acta Pharmaceutica Sinica | 2024, 59(8): 2183-2191
Interactions between gut microbiota-producing enzymes and natural drugs affect disease progression
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Zhi-yu WANG1, Hao-ran SHEN1, Yan-xing HAN1, Jian-dong JIANG1, 3, Wei JIANG2, *, Hui-hui GUO1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Zhejiang Zhenyuan Pharmaceutical Co., Ltd., Shaoxing 312000, China
  • 3. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2024-08-12 doi: 10.16438/j.0513-4870.2024-0363
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Naturally derived metabolites are valuable resources for drug research and development, and play an important role in the treatment of diseases. As the "second genome" of the body, gut microbiota is rich in metabolic enzymes, which interacts with external substances such as drugs, thus affecting the progression of diseases. This article summarizes the interaction between gut microbiota-producing enzymes and natural medicines, and focuses on the impact of this interaction on disease progression, hoping to provide new ideas for the development and pharmacological mechanism of natural medicines.

natural medicine  /  gut microbiota  /  gut microbiota-producing enzyme  /  disease progression  /  drug research and development
Zhi-yu WANG, Hao-ran SHEN, Yan-xing HAN, Jian-dong JIANG, Wei JIANG, Hui-hui GUO. Interactions between gut microbiota-producing enzymes and natural drugs affect disease progression[J]. Acta Pharmaceutica Sinica, 2024 , 59 (8) : 2183 -2191 . DOI: 10.16438/j.0513-4870.2024-0363
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Article Info
doi: 10.16438/j.0513-4870.2024-0363
  • Receive Date：2024-04-15
  • Online Date：2025-11-26
  • Published：2024-08-12
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History
  • Received：2024-04-15
  • Revised：2024-05-13
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Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Zhejiang Zhenyuan Pharmaceutical Co., Ltd., Shaoxing 312000, China
    3. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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