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Two new isocoumarins from cave-derived Metarhizium anisopliae NHC-M3-2
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Rong-xiang WU1, Jie-lan GUO1, Hua HUANG1, Jing-jing LIAO1, Yi HAO1, Fan-dong KONG1, Li-man ZHOU1, *, Chao-jun ZHANG2, *
Acta Pharmaceutica Sinica | 2024, 59(9) : 2588 - 2593
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Acta Pharmaceutica Sinica | 2024, 59(9): 2588-2593
Two new isocoumarins from cave-derived Metarhizium anisopliae NHC-M3-2
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Rong-xiang WU1, Jie-lan GUO1, Hua HUANG1, Jing-jing LIAO1, Yi HAO1, Fan-dong KONG1, Li-man ZHOU1, *, Chao-jun ZHANG2, *
Affiliations
  • 1. Key Laboratory of Universities in Guangxi for Excavation and Development of Ancient Ethnomedicinal Recipes, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China
  • 2. Zhejiang Kanglaite Pharmaceutical Limited Company, Hangzhou 310018, China
Published: 2024-09-12 doi: 10.16438/j.0513-4870.2024-0211
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Extracting extracts of secondary metabolites from the karst cave fungus Metarhizium anisopliae NHC-M3-2 from the Yilingyan Scenic Area in Guangxi. Ten compounds were isolated and purified from fungal secondary metabolites using thin-layer chromatography and high-performance liquid chromatography. 7-Hydroxy-3-hydroxypropyl-5,6-dimethylisochrome-1-one (1) and 7-hydroxy-3,5,6-trimethyl-isochromen-1-one (2) were new isocoumarin compounds, N-acetyl phenylalanine (3), chaetosumin J (4), 2-one-13-hydroxy-3,5,8,7(11)-eudesmatetraen-12,8-olide (5), 1H-indole-3-carboxaldehyde (6), irpexolaceus B (7), irlactin L (8), cytochalasin K (9), and helvolic acid (10), a total of 8 known compounds. The structure of the compound was determined using methods such as NMR and mass spectrometry. The tumor cytotoxicity of the compound was evaluated using the CCK-8 method. The results showed that the IC50 of compound 2 on HepG2 cells was 29.83 µmol·L-1, and compound 9 on HCT116 cells was 27.44 µmol·L-1.

Metarhizium anisopliae NHC-M3-2  /  tumor cytotoxicity  /  isocoumarin compound  /  secondary metabolite
Rong-xiang WU, Jie-lan GUO, Hua HUANG, Jing-jing LIAO, Yi HAO, Fan-dong KONG, Li-man ZHOU, Chao-jun ZHANG. Two new isocoumarins from cave-derived Metarhizium anisopliae NHC-M3-2[J]. Acta Pharmaceutica Sinica, 2024 , 59 (9) : 2588 -2593 . DOI: 10.16438/j.0513-4870.2024-0211
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Article Info
doi: 10.16438/j.0513-4870.2024-0211
  • Receive Date：2024-03-07
  • Online Date：2025-11-24
  • Published：2024-09-12
Article Data
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History
  • Received：2024-03-07
  • Revised：2024-04-28
Funding
Affiliations
    1. Key Laboratory of Universities in Guangxi for Excavation and Development of Ancient Ethnomedicinal Recipes, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China
    2. Zhejiang Kanglaite Pharmaceutical Limited Company, Hangzhou 310018, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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