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Activity evaluation and mechanism study of antibacterial-anti-inflammatory bifunctional Dioscoreae Nipponicae Rhizoma natural components targeting regulatory protein posttranslational modification
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Ru-xu SHEN1, Zi-chen YE2, Jia-qi ZHAO1, Qian ZHANG3, *, Hai-feng TANG3, *, Di QU4, 5, *
Acta Pharmaceutica Sinica | 2024, 59(11) : 2981 - 2989
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Acta Pharmaceutica Sinica | 2024, 59(11): 2981-2989
Activity evaluation and mechanism study of antibacterial-anti-inflammatory bifunctional Dioscoreae Nipponicae Rhizoma natural components targeting regulatory protein posttranslational modification
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Ru-xu SHEN1, Zi-chen YE2, Jia-qi ZHAO1, Qian ZHANG3, *, Hai-feng TANG3, *, Di QU4, 5, *
Affiliations
  • 1. School of Life Sciences, Liaoning University, Shenyang 110036, China
  • 2. Department of Health Service, Medical Service Training Base, Air Force Medical University, Xi'an 710032, China
  • 3. Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China
  • 4. Department of Clinical Pharmacy, General Hospital of Western Theater Command, Chengdu 610000, China
  • 5. Pancreatic Injury and Repair Key Laboratory of Sichuan Province, General Hospital of Western Theater Command, Chengdu 610000, China
Published: 2024-11-12 doi: 10.16438/j.0513-4870.2024-0428
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The phenomenon of bacterial drug resistance is becoming more and more serious. Natural products, as an important resource for drug discovery, can play a role by regulating protein post-translational modifications related to bacterial infection and inflammatory responses. This provides a valuable compound library for the research and development of new antibacterial drugs. In this present research, dioscin and diosgenin were isolated and identified from Dioscorea nipponica Rhizoma, which both exhibited antibacterial activities, with stronger inhibitory on Gram-positive bacteria (G+) than Gram-negative bacteria (G-). Compared these two compounds, diosgenin showed stronger antibacterial activity than dioscin. In vivo experiments confirmed that diosgenin provided better protection against MRSA-induced sepsis in mice compared to dioscin, which could significantly improve survival rates, reduce bacterial colony counts in infected organs, alleviate pathological damage, and decrease inflammatory cytokine levels in mice. The in vivo study was approved by the Animal Ethics Committee of the PLA Air Force Military Medical University (Grant No. 20230188). Network pharmacology results also revealed that diosgenin could target inflammatory pathways, exerting dual antibacterial and anti-inflammatory activities during bacterial infection therapy.

natural product  /  Dioscorea nipponica Rhizoma  /  antibacterial and anti-inflammatory  /  sepsis  /  target prediction  /  protein post-translational modification
Ru-xu SHEN, Zi-chen YE, Jia-qi ZHAO, Qian ZHANG, Hai-feng TANG, Di QU. Activity evaluation and mechanism study of antibacterial-anti-inflammatory bifunctional Dioscoreae Nipponicae Rhizoma natural components targeting regulatory protein posttranslational modification[J]. Acta Pharmaceutica Sinica, 2024 , 59 (11) : 2981 -2989 . DOI: 10.16438/j.0513-4870.2024-0428
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Year 2024 volume 59 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2024-0428
  • Receive Date：2024-05-07
  • Online Date：2025-11-24
  • Published：2024-11-12
Article Data
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History
  • Received：2024-05-07
  • Revised：2024-09-10
Funding
Affiliations
    1. School of Life Sciences, Liaoning University, Shenyang 110036, China
    2. Department of Health Service, Medical Service Training Base, Air Force Medical University, Xi'an 710032, China
    3. Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China
    4. Department of Clinical Pharmacy, General Hospital of Western Theater Command, Chengdu 610000, China
    5. Pancreatic Injury and Repair Key Laboratory of Sichuan Province, General Hospital of Western Theater Command, Chengdu 610000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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