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Targeting protein folding and post-translational modifications by small molecules: review and prospects
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Yan-yi HE1, 2, Qi-dong YOU1, 2, *, Lei WANG1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(11) : 2897 - 2911
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Acta Pharmaceutica Sinica | 2024, 59(11): 2897-2911
Targeting protein folding and post-translational modifications by small molecules: review and prospects
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Yan-yi HE1, 2, Qi-dong YOU1, 2, *, Lei WANG1, 2, *
Affiliations
  • 1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
  • 2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Published: 2024-11-12 doi: 10.16438/j.0513-4870.2024-0503
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Folding and post-translational modification of proteins are vital for their proper functionality, with various functional regulatory systems playing significant roles, including molecular chaperone systems, ubiquitination systems, phosphorylation systems, acetylation systems, etc. Precise regulations of these systems have emerged as an important trend in drug development. This review systematically summarizes the molecular control strategies related to protein folding and post-translational modification, with a specific focus on the molecular chaperone system and the strategy of heterobifunctional molecules. On one hand, based on the similarities and differences in molecular mechanisms and design strategies, we summarize the drug development process targeting the molecular chaperone system. On the other hand, we discuss the design principles and characteristics of dual-functional molecules, and summarize their applications and developments in the precise control of post-translational modifications, aiming to provide new insights for future design.

protein folding  /  post-translational modification  /  molecular chaperone system  /  heterobifunctional molecule  /  molecule drug design
Yan-yi HE, Qi-dong YOU, Lei WANG. Targeting protein folding and post-translational modifications by small molecules: review and prospects[J]. Acta Pharmaceutica Sinica, 2024 , 59 (11) : 2897 -2911 . DOI: 10.16438/j.0513-4870.2024-0503
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Year 2024 volume 59 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2024-0503
  • Receive Date：2024-05-27
  • Online Date：2025-11-24
  • Published：2024-11-12
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History
  • Received：2024-05-27
  • Revised：2024-07-23
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Affiliations
    1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
    2. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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